When to increase insulin dose?

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How to Check if You Need to Increase Insulin by 2 Units

Increase your basal insulin dose by 2 units if 50% or more of your fasting fingerstick glucose values over one week are above your target goal of 90-150 mg/dL (5.0-8.3 mmol/L). 1

Monitoring Protocol for Basal Insulin Adjustment

For Basal (Long-Acting) Insulin Titration

  • Check fasting fingerstick glucose daily for one week before making any dose adjustments 1
  • Count how many fasting values exceed your target range (typically 90-150 mg/dL) 1
  • If ≥50% of fasting values are above goal: increase the basal insulin dose by 2 units 1
  • Target may be adjusted based on overall health status and individual goals of care, particularly in older adults where higher targets may be appropriate to minimize hypoglycemia risk 1, 2

Safety Check Before Increasing

Do NOT increase insulin if you have had >2 fasting fingerstick values per week <80 mg/dL (<4.4 mmol/L) - instead, you should decrease the dose by 2 units to prevent dangerous hypoglycemia 1

Monitoring Protocol for Prandial (Mealtime) Insulin

For Premeal Insulin Adjustments

  • Check fingerstick glucose before lunch and before dinner over a 2-week period 1
  • Target premeal glucose: 90-150 mg/dL (5.0-8.3 mmol/L) 1
  • If 50% of premeal values over 2 weeks are above goal: increase the dose or add another glucose-lowering agent 1
  • If >2 premeal values per week are <90 mg/dL (<5.0 mmol/L): decrease the medication dose 1

Critical Timing Considerations

The timing of glucose checks must match the insulin type being adjusted:

  • Basal insulin adjustments: based on fasting (morning) glucose values over 1 week 1
  • Prandial insulin adjustments: based on premeal glucose values over 2 weeks 1
  • Increase frequency of blood glucose monitoring during any insulin regimen changes 3

Common Pitfalls to Avoid

  • Don't adjust too quickly: Basal insulin requires one full week of data; prandial insulin requires two weeks 1
  • Don't ignore hypoglycemia: Even one or two low readings per week (<80 mg/dL fasting or <90 mg/dL premeal) should prompt dose reduction, not increase 1
  • Don't use the wrong glucose reading: Fasting glucose guides basal insulin; premeal glucose guides prandial insulin 1
  • Don't make adjustments without medical supervision when possible, especially during initial titration phases 3

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Novolog 70/30 Dosing Recommendations for Type 2 Diabetes

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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