Yes, Acetaminophen and Paracetamol Are the Same Drug
Acetaminophen and paracetamol are identical medications—simply different names for the same chemical compound used in different regions of the world. 1
Nomenclature by Region
- Acetaminophen is the name used primarily in the United States and Canada 1
- Paracetamol is the name used in most other countries, including the United Kingdom, Australia, and throughout Europe 1, 2
- Both names refer to the same analgesic and antipyretic medication with identical pharmacological properties 2, 3
Clinical Properties
The drug, regardless of which name is used, has the following characteristics:
- Analgesic and antipyretic effects without significant anti-inflammatory activity 4, 3
- First-line treatment for mild to moderate pain in adults and children 1, 5
- Preferred over NSAIDs in patients with contraindications such as aspirin-sensitive asthma, peptic ulcer disease, gastrointestinal bleeding risk, or cardiovascular disease 5, 3
Safety Profile
- Generally well-tolerated at recommended doses (≤4 g/day in adults) 5, 3
- Hepatotoxicity risk exists with overdose or chronic excessive use, which led to FDA recommendations limiting acetaminophen/paracetamol to 325 mg per dosage unit in combination opioid products 4
- Safer gastrointestinal profile compared to NSAIDs, with no increased risk of bleeding or perforation 4
Common Pitfall to Avoid
- Accidental overdose can occur because acetaminophen/paracetamol is included in numerous over-the-counter and prescription combination products (e.g., with codeine, hydrocodone, or other opioids) 4, 6
- Patients may unknowingly exceed safe daily limits by taking multiple products containing the same drug under different brand names 4, 7