Can Ozempic (semaglutide) be used for weight loss only?

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Last updated: March 28, 2025 • View editorial policy

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From the Guidelines

Ozempic (semaglutide) can be used for weight loss, but it is essential to note that it is not FDA-approved specifically for weight loss alone, and its use for this purpose would be considered "off-label". For weight loss purposes, the same medication is marketed as Wegovy at higher doses. Ozempic is approved for treating type 2 diabetes, while Wegovy is specifically approved for chronic weight management in adults with obesity (BMI ≥30) or overweight (BMI ≥27) with at least one weight-related condition.

Key Points to Consider

  • The medication works by mimicking a hormone called GLP-1 that targets areas in the brain that regulate appetite and food intake, making you feel fuller longer and reducing hunger.
  • Common side effects include nausea, vomiting, diarrhea, abdominal pain, and constipation.
  • Weight loss medications are most effective when combined with lifestyle changes including diet and exercise.
  • According to the most recent and highest quality study, the AGA suggests using semaglutide 2.4 mg with lifestyle interventions, compared with lifestyle interventions alone, in adults with obesity or overweight with weight-related complications 1.
  • The STEP trials examined the efficacy of semaglutide and showed significant weight loss at 68 weeks, with a mean weight loss of 14.9% and 16.0% in the STEP 1 and STEP 3 trials, respectively, compared to placebo 1.
  • The SELECT study showed a significant reduction in the incidence of cardiovascular death, MI, or stroke in patients with pre-existing CVD who were overweight or obese, but without diabetes, treated with weekly subcutaneous semaglutide 1.

Recommendations

  • If you're considering medication for weight loss, it's essential to consult with a healthcare provider who can determine if you're a suitable candidate and discuss appropriate options based on your specific health situation.
  • The use of semaglutide for weight loss should be considered in the context of overall health and the presence of weight-related complications.
  • Lifestyle interventions, including diet and exercise, should be combined with pharmacotherapy for optimal weight loss results.

References

1
Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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