From the Research
Significance of Elevated Anti-Müllerian Hormone (AMH)
Elevated Anti-Müllerian Hormone (AMH) levels have been associated with several clinical implications, including:
- Polycystic Ovary Syndrome (PCOS): Studies have shown that women with elevated AMH levels (>10 ng/mL) have a higher prevalence of PCOS phenotypes, including polycystic ovarian morphology and oligoamenorrhea 1.
- Ovarian Reserve: AMH is a useful marker for assessing ovarian reserve, with higher levels indicating a greater number of antral follicles 2, 3.
- Assisted Reproductive Technology (ART): Elevated AMH levels have been linked to higher rates of ovarian hyperstimulation syndrome and clinical pregnancy rates following ART 1.
- Ovarian Tumors: AMH can be used as a tumor marker for granulosa cell tumors and other ovarian tumors 4, 5.
- Insulin Resistance: Elevated AMH levels have been associated with insulin resistance and hyperandrogenism in women with PCOS 4.
Clinical Applications of AMH
The clinical applications of AMH include:
- Diagnosis of PCOS: AMH can be used as a diagnostic marker for PCOS, particularly in women with elevated AMH levels (>10 ng/mL) 1.
- Assessment of Ovarian Reserve: AMH can be used to assess ovarian reserve and predict the likelihood of successful ovarian stimulation and pregnancy rates following ART 2, 3.
- Monitoring of Ovarian Tumors: AMH can be used to monitor the response to therapy and detect recurrence of ovarian tumors 4, 5.
- Prediction of Ovarian Reserve after Cancer Therapy: AMH has been proposed as a predictor of ovarian reserve after completion of cancer therapy 5.