Can foodborne illnesses be transmitted through seafood?

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Last updated: November 8, 2025View editorial policy

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Can Foodborne Illnesses Be Transmitted Through Seafood?

Yes, seafood is a significant source of foodborne illnesses and should never be consumed raw or undercooked, as it can transmit multiple bacterial, viral, and parasitic infections that cause substantial morbidity and mortality.

Risk Magnitude

  • Seafood accounts for 10-19% of all foodborne illnesses in the United States, ranking third among food products causing foodborne disease 1, 2
  • While viruses cause approximately half of seafood-related infections, bacterial agents are responsible for most hospitalizations and deaths 3
  • Vibrio vulnificus infection from seafood consumption is the leading cause of death related to seafood in the United States, with case-fatality rates exceeding 50% for primary septicemia 4

Specific Pathogens Transmitted Through Seafood

Bacterial Infections

  • At least 10 genera of bacterial pathogens cause seafood-borne diseases, with naturally-occurring bacteria (particularly Vibrio species) accounting for 20% of shellfish-related illnesses and 99% of deaths 2
  • Vibrio species (including V. vulnificus, V. parahaemolyticus, and V. cholerae), Salmonella, and Campylobacter are commonly transmitted through contaminated seafood 5, 4
  • Listeria can be transmitted through ready-to-eat seafood products 5

Viral Infections

  • Viruses are the most common cause of shellfish-associated disease, with Norwalk virus and small round structured viruses responsible for the majority of outbreaks 2
  • Hepatitis A virus transmission through shellfish has been documented 2
  • Viral gastroenteritis from Vibrio species and Cryptosporidium parvum can be transmitted through raw or undercooked seafood 5

Parasitic Infections

  • Multiple parasites including nematodes, trematodes, cestodes, and protozoa are readily transmitted through seafood consumption 6

High-Risk Populations

Immunocompromised individuals face dramatically elevated risk and must exercise extreme caution:

  • HIV-infected persons, particularly those with severe immunosuppression, should avoid all raw or undercooked seafood 5
  • Patients with liver disease are more susceptible to severe infections, particularly Vibrio vulnificus septicemia with mortality rates exceeding 50% 4, 3
  • Hematopoietic stem cell transplant recipients must avoid raw or undercooked seafood to prevent viral gastroenteritis and Vibrio species infections 5

Prevention Guidelines

Cooking Requirements

  • All seafood must be cooked until well done with no pink remaining in the middle (internal temperature >165°F or 73.8°C) 5
  • This cooking temperature is critical for killing bacterial, viral, and parasitic pathogens 3, 6

Cross-Contamination Prevention

  • Uncooked seafood must never contact other foods 5
  • Hands, cutting boards, counters, knives, and all utensils must be washed thoroughly after contact with uncooked seafood 5

Travel Considerations

  • When traveling to developing countries, avoid raw or undercooked seafood entirely, as the risk for foodborne infections is magnified in these settings 5
  • Safe alternatives include steaming-hot foods, bottled beverages, and water boiled for 1 minute 5, 7

Common Pitfalls to Avoid

  • Do not assume that fresh or high-quality seafood is safe to consume raw—naturally-occurring pathogens like Vibrio species are not related to fecal contamination and cannot be predicted by standard food safety indicators 2
  • Avoid oysters and clams entirely if immunocompromised, as these filter-feeding shellfish concentrate pathogens and are particularly high-risk 5
  • Temperature abuse is a major cause of scombroid poisoning from tuna, mahi-mahi, and related species, so proper refrigeration is essential 2
  • Freezing does not eliminate all parasites, and adequate cooking remains the safest prevention method 6

References

Research

The role of seafood in foodborne diseases in the United States of America.

Revue scientifique et technique (International Office of Epizootics), 1997

Research

Vibrio vulnificus infection: diagnosis and treatment.

American family physician, 2007

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Treatment for Headache and Vomiting Following Contaminated Food

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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