What is the first-line treatment for neonatal fever?

From the Research

First-Line Treatment for Neonatal Fever

The first-line treatment for neonatal fever is not explicitly stated in the provided studies as a specific medication or intervention. However, the management and evaluation of febrile infants are discussed in detail.

Evaluation and Management

• The American Academy of Pediatrics (AAP) has published guidelines for the evaluation and management of well-appearing febrile infants from age 8 to 60 days 1.
• Neonates (infants under 28 days) with fever should be admitted to the hospital 2.
• Young infants in the second month of life may be risk-stratified, and those deemed low-risk on testing may be sent home with close follow-up 2.
• The AAP guidelines focus on management and treatment guidelines for three age groups: 8 to 21 days, 22 to 28 days, and 29 to 60 days 3.

Laboratory Evaluation

• Initial laboratory work, including blood and urine tests, is crucial in evaluating febrile infants 3.
• Cerebrospinal fluid studies may not be necessary if initial laboratory work is reassuring, especially in the 22- to 28-day and 29- to 60-day age groups 3.

Antibiotic Use

• Not all febrile infants require hospitalization or empiric treatment with antibiotics 4.
• Antibiotics may be considered for febrile infants who are at high risk for serious bacterial infection (SBI) or who have a confirmed bacterial infection 4, 2.