From the Guidelines
The recommended dose of lactose is 1 g/kg up to 15 g (60 mL) every 6 h as needed when administered orally, and 1 g/kg up to 50 g every 6 h as needed when administered rectally. This dose is based on the study published in the journal Pediatrics in 2008 1. The study provides dosage guidelines for various medications, including lactose, in the context of preparing for pediatric emergencies. Key points to consider when administering lactose include:
- The dose is weight-based, with a maximum dose of 15 g (60 mL) orally and 50 g rectally every 6 hours as needed.
- The dosage may vary depending on the individual's response and the specific clinical scenario.
- It is essential to follow the recommended dosage guidelines to minimize the risk of adverse effects and ensure the safe use of lactose. In clinical practice, it is crucial to consider the individual patient's needs and adjust the dose accordingly, taking into account factors such as age, weight, and medical history 1.
From the Research
Lactose Intolerance and Dose
- The degree of lactose malabsorption varies greatly among patients with lactose intolerance, but most of them can ingest up to 12 oz of milk daily without symptoms 2.
- Most individuals with lactose intolerance can tolerate up to 12 grams of lactose, though symptoms become more prominent at doses above 12 grams and appreciable after 24 grams of lactose 3.
- A daily divided dose of 24 grams was generally tolerated 3.
- The likelihood of lactose intolerance depends on the lactose dose, lactase expression, and the intestinal microbiome 4.
- Symptoms of lactose intolerance, such as abdominal pain, bloating, and diarrhea, occur after the consumption of lactose due to a deficiency in lactase-phlorizin hydrolase (LPH) 5.
Diagnostic Tests and Treatment
- Diagnostic investigations available to diagnose lactose malabsorption and intolerance include genetic, endoscopic, and physiological tests 4.
- The hydrogen breath test (HBT) is a popular technology to aid in the diagnosis of lactose intolerance due to its relatively low cost, availability, and non-invasiveness 5.
- Treatment of lactose intolerance can include a low-lactose diet, lactase supplementation, and potentially, colonic adaptation by prebiotics 4.
- Most individuals with presumed lactose intolerance or malabsorption can tolerate 12-15 grams of lactose (approximately 1 cup of milk) 3.