Interpretation of Laboratory Results
This patient has no evidence of current or past infection with hepatitis B, hepatitis C, herpes simplex virus types 1 or 2, or syphilis—all results are negative and no further testing or treatment is indicated for these infections.
Hepatitis B Status
- HBsAg (Hepatitis B Surface Antigen): Non-Reactive indicates no current hepatitis B infection 1
- HBsAb (Hepatitis B Surface Antibody): Non-Reactive indicates no immunity from either past infection or vaccination 1
- Interpretation: The patient is susceptible to hepatitis B virus infection and should be offered hepatitis B vaccination 1
Hepatitis C Status
- HCV Antibody: Non-Reactive indicates no antibody to hepatitis C virus detected 2
- Interpretation: The patient has no serologic evidence of hepatitis C infection 2
- No further HCV RNA testing is needed since the antibody screening test is non-reactive 2
- The patient should be reassured if any past exposure was remote 2
Herpes Simplex Virus Status
- HSV-1 IgG: <0.01 AI (Negative) indicates no IgG antibody to herpes simplex virus type 1 detected
- HSV-2 IgG: 0.05 AI (Negative) indicates no IgG antibody to herpes simplex virus type 2 detected
- Interpretation: The patient has never been infected with either HSV-1 or HSV-2
- Both values are well below the 0.90 AI threshold for positivity
Syphilis Status
- RPR: Non-Reactive indicates no serologic evidence of syphilis infection
- Interpretation: The patient has no current or past syphilis infection requiring treatment
Recommended Next Steps
Hepatitis B Vaccination
- Offer hepatitis B vaccination series since the patient lacks both HBsAg and HBsAb, indicating susceptibility to infection 1
- The standard vaccination series consists of 3 doses at 0,1, and 6 months
No Additional Testing Required
- No confirmatory or supplemental testing is needed for any of these infections since all screening tests are negative 2
- HCV RNA testing is only indicated when the HCV antibody test is reactive 2, 3
- Supplemental testing (such as RIBA for HCV) is only performed on screening-test-positive samples 2
Risk Assessment and Counseling
- If the patient has ongoing risk factors for bloodborne or sexually transmitted infections, provide counseling on risk reduction 2
- Consider repeat testing only if there was a recent exposure within the past 6 months, as antibodies may not yet be detectable during the window period 2
Clinical Context Considerations
- These results represent a single point in time and reflect no evidence of infection at the time of testing
- If acute hepatitis C is suspected clinically despite negative antibody testing, HCV RNA testing may be warranted as antibody can be negative early in infection 2
- For hepatitis B, antibody seroconversion typically occurs within 6 months of exposure, so recent exposures may require follow-up testing 1