Can glutathione premix injection at 2000 milligrams be added to a Nicotinamide adenine dinucleotide (NAD+) injection?

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Last updated: March 29, 2025View editorial policy

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From the Research

I strongly advise against adding glutathione premix injection at 2000 mg to an NAD+ injection without proper medical supervision. The combination of these two compounds could potentially alter their stability, efficacy, and safety profile, leading to adverse reactions or reduced effectiveness. Glutathione is a tripeptide antioxidant, while NAD+ (nicotinamide adenine dinucleotide) is a coenzyme involved in metabolic processes. The high concentration of glutathione (2000 mg) could potentially cause chemical interactions with NAD+, affecting the pH or creating precipitates.

According to a recent study 1, supplementing GlyNAC (a combination of glycine and N-acetylcysteine) in older adults improved glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, physical function, and aging hallmarks. However, this study does not support the combination of glutathione with NAD+ injections.

Another study 2 found that oral glutathione supplementation increased body stores of glutathione in healthy adults, but this does not necessarily apply to injectable forms or combinations with other compounds like NAD+.

The potential risks of improper mixing or administration of injectable compounds, including infection, embolism, or adverse reactions, outweigh any potential benefits of combining glutathione and NAD+ injections. It is crucial to consult with a healthcare provider before combining any injectable medications or supplements, as they can properly assess compatibility, appropriate dosing, and individual health needs.

Some key points to consider:

  • Glutathione and NAD+ have different properties and optimal storage conditions
  • High concentrations of glutathione could cause chemical interactions with NAD+
  • Improper mixing or administration of injectable compounds carries significant risks
  • Consultation with a healthcare provider is essential before combining injectable medications or supplements

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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