What is the optimal method for administering a 2000 milligram (mg) intravenous (IV) infusion of glutathione?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Article Review Status
Submitted
Under Review
Approved

Last updated: March 29, 2025 • View editorial policy

From the Research

The best way to give a 2000 mg infusion of glutathione is through slow intravenous (IV) administration over 15-30 minutes, diluted in 50-100 mL of normal saline or 5% dextrose solution, as this method allows for optimal absorption and minimizes potential side effects. When preparing the infusion, it is essential to use pharmaceutical-grade glutathione and follow sterile conditions to prevent contamination. According to a study on the compatibility of reduced glutathione with different solutions 1, glutathione is compatible with 0.9% saline and 5% glucose solution, making these suitable options for dilution.

Prior to administration, the patient should be in a comfortable position with IV access established using a 20-22 gauge needle. Vital signs should be monitored before, during, and after the infusion to ensure the patient's safety. The infusion rate should start slowly and increase gradually to minimize potential side effects such as flushing or lightheadedness. Although oral glutathione supplementation has been shown to be effective in increasing body stores of glutathione 2, IV administration is preferred for optimal absorption and bioavailability. Glutathione infusions are typically administered 1-3 times weekly, depending on the condition being treated, and this approach allows the antioxidant to circulate throughout the body's tissues where it can neutralize free radicals and support detoxification processes.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.