Treatment of Acute Bronchitis
Antibiotics should NOT be routinely prescribed for acute bronchitis, as they provide minimal benefit (reducing cough by only about half a day) while exposing patients to adverse effects and contributing to antibiotic resistance. 1, 2
Initial Assessment and Diagnosis
Before treating for acute bronchitis, rule out pneumonia by checking for:
- Tachycardia (heart rate >100 beats/min) 2
- Tachypnea (respiratory rate >24 breaths/min) 2
- Fever (oral temperature >38°C) 2
- Abnormal chest examination findings (rales, egophony, tactile fremitus) 2
No routine investigations are recommended including chest x-ray, spirometry, sputum culture, viral PCR, or inflammatory markers (CRP, procalcitonin) at initial presentation. 1
Symptomatic Treatment Approach
First-Line Therapy: Bronchodilators
Albuterol (short-acting β2-agonist) is the recommended first-line symptomatic treatment for patients with evidence of bronchial hyperresponsiveness such as wheezing or bothersome cough. 3
- Approximately 50% fewer patients report cough after 7 days of albuterol treatment compared to placebo 1, 3
- Treatment reduces both duration and severity of cough 1, 3
- Do NOT routinely use β2-agonists in patients without wheezing or clinical evidence of bronchial hyperresponsiveness 2, 4
Second-Line: Antitussives
For patients with persistent bothersome cough:
- Dextromethorphan or codeine provide modest effects on cough severity and duration 1, 2, 4
- These agents are more effective for cough lasting >3 weeks or cough associated with underlying lung disease 1
Adjunctive Measures
Low-cost, low-risk interventions are reasonable:
- Elimination of environmental cough triggers (dust, dander) 1, 3
- Vaporized air treatments, particularly in low-humidity environments 1, 3
When Antibiotics Are NOT Indicated
The presence of purulent sputum or change in sputum color does NOT signify bacterial infection and is NOT an indication for antibiotics. 2
Antibiotics reduce cough duration by only approximately 0.5 days while causing side effects and promoting resistance. 5
Exception: When to Consider Antibiotics
Pertussis (Whooping Cough)
- Prescribe a macrolide antibiotic (erythromycin) for confirmed or suspected pertussis 2
- Isolate patients for 5 days from start of treatment 2, 4
- Early treatment within first few weeks diminishes coughing paroxysms and prevents spread 2
Worsening Bronchitis
- Consider antibiotics only if the condition significantly worsens, suggesting bacterial superinfection 1, 3
- Reassess and consider targeted investigations if symptoms persist or worsen 1
Influenza-Related Bronchitis
- Consider antiviral agents if within 48 hours (preferably <30 hours) of symptom onset during documented influenza outbreaks 1, 2
Patient Communication Strategy
Patient satisfaction depends more on physician-patient communication than whether an antibiotic is prescribed. 1, 2
Key Points to Discuss:
- Inform patients that cough typically lasts 10-14 days after the office visit 2, 3, 4
- Refer to the condition as a "chest cold" rather than "bronchitis" to reduce antibiotic expectations 2, 4
- Explain the lack of benefit of antibiotics for uncomplicated acute bronchitis 1, 2
- Discuss potential harm of unnecessary antibiotic use including side effects and contribution to resistance 2, 4
Common Pitfalls to Avoid
- Do not prescribe antibiotics based solely on colored or purulent sputum 2, 4
- Do not routinely use NSAIDs at anti-inflammatory doses or systemic corticosteroids for acute bronchitis 2, 4
- Do not fail to distinguish between acute bronchitis and pneumonia before initiating treatment 4
- Do not overlook bronchodilator therapy which has demonstrated benefit in appropriate patients 3