Is Rejuvia (unknown generic name) Sleep Spray safe to use for sleep improvement?

Rejuvia Sleep Spray: Safety and Efficacy Assessment

I cannot recommend Rejuvia Sleep Spray for sleep improvement due to the complete absence of safety data, efficacy evidence, and regulatory oversight for this specific product.

Critical Product Information Gap

• No identifiable active ingredient: The generic name and formulation of Rejuvia Sleep Spray are unknown, making any safety or efficacy assessment impossible 1
• No FDA approval or oversight: As a spray formulation marketed for sleep, this product likely falls under the unregulated dietary supplement category in the United States, where no regulatory agency oversees manufacturing quality, ingredient accuracy, or safety 2
• Absence from clinical guidelines: Neither the American Academy of Sleep Medicine nor the American College of Physicians guidelines reference any sleep spray products as evidence-based treatments 1

Evidence-Based Alternatives You Should Use Instead

First-Line Treatment

• Cognitive Behavioral Therapy for Insomnia (CBT-I) is the gold standard first-line treatment, demonstrating superior long-term efficacy compared to any pharmacotherapy 3

FDA-Approved Pharmacologic Options (When CBT-I Fails)

For sleep onset insomnia:

• Zolpidem 10 mg: Reduces sleep latency by 29 minutes and improves total sleep time by 29 minutes compared to placebo 1
• Eszopiclone 2-3 mg: Improves total sleep time by 28-57 minutes with moderate-to-large improvements in sleep quality 1

For sleep maintenance insomnia:

• Low-dose doxepin 3-6 mg: Reduces wake after sleep onset by 22-23 minutes with favorable safety profile 1, 3
• Suvorexant 10-20 mg: Reduces wake after sleep onset by 16-28 minutes, though with modest overall effect 1, 4

Why Common Over-the-Counter "Sleep Sprays" Are Problematic

If Rejuvia Contains Melatonin:

• Not recommended by AASM: Melatonin shows only 9-minute reduction in sleep latency with small improvements in quality, insufficient for clinical recommendation 1
• Unregulated dosing: Studies show marketed melatonin products vary wildly from labeled concentrations, with no quality control 2
• Limited efficacy: While safe, melatonin's sleep-inducing ability is "detectable but modest for most people" 5, 2

If Rejuvia Contains Antihistamines (Diphenhydramine/Doxylamine):

• Explicitly not recommended: The AASM found no improvement in sleep quality compared to placebo, with only 8-minute reduction in sleep latency 1
• Significant harms in elderly: Associated with daytime drowsiness, falls, fractures, cognitive impairment, and anticholinergic effects 6, 7
• Tolerance develops rapidly: Efficacy diminishes with continued use 7

If Rejuvia Contains Herbal Ingredients (Valerian, etc.):

• Not recommended: Valerian shows only 9-minute reduction in sleep latency with no quality improvement, insufficient evidence for recommendation 1
• Consider continuing only if already using: The Society for Perioperative Assessment notes valerian "appears safe" but provides "no objective benefit for sleep latency or quality" 1

Critical Safety Concerns with Unregulated Sleep Products

• Unknown drug interactions: Without knowing the active ingredients, risk assessment for interactions with your current medications is impossible 6
• Contamination risk: Unregulated supplements may contain unlisted ingredients, contaminants, or incorrect dosages 2
• Delayed appropriate treatment: Using ineffective products postpones evidence-based interventions that could meaningfully improve your sleep and quality of life 3

What You Should Do Instead

1. Pursue CBT-I first: This non-pharmacologic approach provides durable benefits without medication risks 3

2. If pharmacotherapy needed, discuss FDA-approved options with your physician:

   • For difficulty falling asleep: Zolpidem or eszopiclone 1
   • For difficulty staying asleep: Low-dose doxepin or suvorexant 1, 3, 4

3. Avoid over-the-counter sleep aids: Diphenhydramine, doxylamine, and most herbal products lack evidence and carry meaningful risks, particularly cognitive impairment and falls 1, 7

Common Pitfalls to Avoid

• Do not assume "natural" or "spray" formulations are safer: Lack of regulation means unknown ingredients and concentrations 2
• Do not use antihistamines chronically for sleep: Tolerance develops rapidly and harms outweigh minimal benefits 1, 7
• Do not delay seeking proper evaluation: Chronic insomnia requires assessment for underlying causes and evidence-based treatment 1, 3