From the Research
There is limited scientific evidence that DIM (diindolylmethane) significantly affects body composition in men. DIM is a compound found in cruciferous vegetables and available as a supplement, but research specifically examining its effects on male body composition (muscle mass, fat distribution, etc.) is insufficient to make strong claims. While DIM may influence estrogen metabolism by promoting the production of beneficial estrogen metabolites and potentially reducing the activity of more potent forms of estrogen, these effects have not been conclusively shown to translate to meaningful changes in body composition for men. Some men take DIM supplements (typically 100-300mg daily) hoping to achieve a more favorable testosterone-to-estrogen ratio, but such effects remain largely theoretical or anecdotal.
Key Considerations
- The most recent and highest quality study on DIM and body composition is not directly related to men, but rather focuses on its effects in premenopausal women, as seen in the study by 1.
- DIM has been shown to have various biological activities, including antiplatelet aggregation and antithrombotic effects, as demonstrated in the study by 2, but these effects do not directly relate to body composition in men.
- The safety profile of DIM, especially in the context of long-term supplementation, is not fully established, which is a critical consideration for men looking to use DIM for body composition purposes.
- Established methods for improving body composition, such as resistance training, adequate protein intake, and overall calorie management, have robust evidence supporting their effectiveness and should be prioritized over supplementation with DIM.
Recommendation
Given the current state of evidence, it is recommended that men focus on established methods for improving body composition rather than relying on DIM supplementation. Any consideration of DIM or other supplements should be discussed with a healthcare provider, taking into account potential interactions with medications and the lack of comprehensive data on long-term safety and efficacy for body composition goals.