Supporting Immunity Through Vaccination
The most effective way to support immunity is through adherence to age-appropriate vaccination schedules as recommended by the Advisory Committee on Immunization Practices (ACIP), which provides protection against vaccine-preventable diseases throughout the lifespan. 1
Core Vaccination Strategy by Age Group
Adults 19-64 Years
- Annual influenza vaccination is recommended for all adults to prevent disease and reduce transmission 1
- Tdap vaccine (tetanus, diphtheria, pertussis): One dose if not previously received, followed by Td booster every 10 years 1
- During pregnancy: Tdap during each pregnancy, preferably during gestational weeks 27-36, to protect both mother and newborn 1
Adults 65 Years and Older
- Pneumococcal vaccination series: PCV13 followed by PPSV23 at least 1 year later provides critical protection against pneumococcal disease 1
- Zoster (shingles) vaccine: 2-dose RZV series (2-6 months apart) starting at age 50 years or older 1
- Annual influenza vaccination remains essential 1
Special Populations Requiring Enhanced Protection
Immunocompromised individuals require tailored vaccination approaches 1:
- Can safely receive inactivated vaccines (influenza, pneumococcal, hepatitis B) 1
- Should avoid live vaccines (MMR, varicella, zoster live vaccine) due to risk of vaccine-strain disease 1
- May have reduced vaccine effectiveness depending on degree of immune dysfunction 1
- Household contacts must be fully vaccinated to create a protective barrier around immunocompromised individuals 1
Healthcare personnel should ensure immunity to measles, mumps, rubella, varicella, hepatitis B, and receive annual influenza vaccination 1
Critical Implementation Principles
Timing and Adherence
- Adherence to recommended schedules is paramount - delays leave individuals vulnerable to preventable diseases 2, 3
- Only 63% of children follow recommended vaccination patterns, with 37% experiencing delays that increase disease susceptibility 2
- Every medical encounter should be used as an opportunity to update vaccination status 1, 4
Common Pitfalls to Avoid
- Do not delay vaccination for minor illnesses without fever - this is a precaution, not a contraindication 1
- Pregnancy is NOT a contraindication for inactivated vaccines (influenza, Tdap) - these are specifically recommended 1
- Do not confuse precautions with contraindications - only severe allergic reactions and specific immunodeficiency states are true contraindications 1
Contraindications vs. Precautions
True contraindications (never give vaccine) 1:
- Severe allergic reaction (anaphylaxis) to vaccine component
- Severe immunodeficiency for live vaccines only
- Pregnancy for live vaccines (MMR, varicella, live zoster)
Precautions (may delay but not avoid) 1:
- Moderate to severe acute illness with or without fever
- Recent receipt of antibody-containing blood products (for live vaccines)
Beyond Vaccination: Supporting Immune Function
While vaccination is the cornerstone of immune support, healthy diet and regular exercise form a complementary triad for optimal immune function across the lifespan 5
System-Level Strategies
- Implement reminder/recall systems to improve vaccination rates 1
- Ensure bidirectional flow between immunization information systems and electronic health records 1
- Provide vaccine information statements (VIS) and document discussions about risks and benefits 1
The evidence is clear: life-course immunization beginning in childhood and continuing throughout adulthood reduces morbidity and mortality, particularly in older adults who face increased vulnerability to vaccine-preventable diseases. 6, 5