From the Guidelines
Desmoxan, also known as desmopressin, is a safe and effective treatment for nocturnal enuresis, particularly in children with nocturnal polyuria, and should be considered as a therapeutic option with a recommended oral formulation and careful monitoring of fluid intake to avoid water intoxication and hyponatremia. When considering Desmoxan for treatment, it's essential to evaluate the child's condition and medical history, as desmopressin is most efficient in children with nocturnal polyuria and normal bladder reservoir function 1. The treatment should be accompanied by counseling on regular voiding, optimal posture, and bowel habits, as well as encouragement of physical activity and a normal lifestyle despite the condition. Key aspects of Desmoxan treatment include:
- Oral formulations are preferred due to the risk of water intoxication and hyponatremia associated with the nasal spray 1
- Evening fluid intake should be limited to 200 ml (6 ounces) or less to minimize the risk of water intoxication 1
- Desmoxan can cause side effects, but they are generally mild and rare, with the most significant concern being water intoxication with excessive fluid intake 1
- The treatment has a low curative potential, with approximately 30% of children experiencing a full response and 40% having a partial response 1
- Desmoxan's antidiuretic activity and potential central nervous system effects contribute to its beneficial effects in treating enuresis 1
From the FDA Drug Label
CLINICAL PHARMACOLOGY Desmopressin acetate tablets contain as active substance, desmopressin acetate, a synthetic analogue of the natural hormone arginine vasopressin. Central Diabetes Insipidus Dose response studies in patients with diabetes insipidus have demonstrated that oral doses of 0.025 mg to 0.4 mg produced clinically significant antidiuretic effects. In most patients, doses of 0. 1 mg to 0.2 mg produced optimal antidiuretic effects lasting up to eight hours. With doses of 0. 4 mg, antidiuretic effects were observed for up to 12 hours; measurements beyond 12 hours were not recorded.
The primary use of Desmoxan is for the treatment of Central Diabetes Insipidus.
- The effective dose range is 0.025 mg to 0.4 mg.
- Optimal antidiuretic effects are achieved with doses of 0.1 mg to 0.2 mg, lasting up to 8 hours.
- A dose of 0.4 mg produces antidiuretic effects for up to 12 hours 2.
From the Research
Desmoxan Information
- There are no research papers to assist in answering this question about Desmoxan.
- The provided studies discuss antioxidants, their properties, and methods for determining antioxidant activity 3, 4, 5, 6, 7.
- These studies do not mention Desmoxan, and therefore, no information can be provided about it based on the available evidence.
- Antioxidants are molecules that can inhibit the oxidation of other molecules, and they play a crucial role in protecting against free radical-induced damage 3.
- Various methods are used to determine the antioxidant activity of different compounds, including 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and 2'-azobis(2-amidinopropane)dihydrochloride (AAPH) induced linoleic oxidation assays 4, 5.