Does the efficacy of Dayvigo (Lemborexoucheric) decrease over time?

From the Guidelines

Dayvigo (lemborexant) may experience some tolerance over time, but this varies among individuals, and there is limited evidence available on its long-term effects. Some patients report continued effectiveness with long-term use, while others notice diminishing effects after weeks or months of regular use. If you find Dayvigo becoming less effective, speak with your healthcare provider before adjusting your dose. They might recommend temporary discontinuation (drug holiday), dose adjustment, or switching to another medication. Tolerance occurs because your brain adapts to the medication's presence, making the same dose less effective over time. To maximize Dayvigo's effectiveness, maintain good sleep hygiene practices alongside medication use, including consistent sleep schedules, limiting screen time before bed, and creating a comfortable sleep environment. If you're concerned about tolerance, track your sleep quality and discuss any changes with your healthcare provider.

Key Considerations

• The evidence provided does not directly address the long-term effects of Dayvigo, but it discusses the management of chronic insomnia disorder and the potential for tolerance with other medications 1.
• Cognitive behavioral therapy for insomnia (CBT-I) is recommended as a first-line treatment for chronic insomnia disorder, with evidence showing its effectiveness in improving sleep outcomes 1.
• Pharmacotherapy, including nonbenzodiazepine benzodiazepine receptor agonists, may be considered for patients who are unable or unwilling to receive CBT-I, but the potential benefits and harms should be carefully weighed 1.
• Antihistamines and antipsychotics are not recommended for the treatment of chronic insomnia disorder due to their adverse effect profiles and limited evidence supporting their efficacy 1.

Recommendations

• If you are concerned about the effectiveness of Dayvigo over time, consult with your healthcare provider to discuss potential adjustments to your treatment plan.
• Prioritize good sleep hygiene practices to maximize the effectiveness of Dayvigo and improve overall sleep quality.
• Consider CBT-I as a first-line treatment for chronic insomnia disorder, given its strong evidence base and potential for long-term benefits.

From the Research

Dayvigo Effect Over Time

• The effect of Dayvigo (lemborexant) on insomnia disorder has been studied in several clinical trials, with results indicating its efficacy in improving sleep onset and maintenance 2, 3, 4, 5, 6.
• In a 12-month study, lemborexant 5 mg and 10 mg demonstrated significant improvements in sleep onset latency, sleep efficiency, total sleep time, and wake after sleep onset compared to placebo, with these improvements sustained through month 12 2.
• A network meta-analysis comparing lemborexant with other insomnia treatments found that lemborexant had the highest probability of being the best treatment for three of four objectively measured insomnia efficacy outcomes at 4 weeks, and its safety profile was broadly similar to other insomnia treatments 3.
• Another study comparing lemborexant with zolpidem tartrate extended-release found that lemborexant provided significant benefits for sleep-onset latency, total sleep time, and wake after sleep onset in participants with insomnia with objective short sleep duration, while zolpidem ER also provided significant benefits for total sleep time and wake after sleep onset 4.
• A phase 3 randomized clinical trial found that lemborexant therapy significantly improved both sleep onset and sleep maintenance, including in the second half of the night, compared with both placebo and zolpidem, and was well tolerated 6.
• Overall, the evidence suggests that the effect of Dayvigo does not wear off over time, with sustained improvements in sleep parameters observed in clinical trials 2, 3, 4, 5, 6.