From the Research
There is generally no significant issue with taking NAD+ peptides if you have MTHFR gene mutations, but individual responses may vary. MTHFR mutations affect methylation pathways and folate metabolism, while NAD+ supplementation works through different biological mechanisms related to energy production and cellular repair. In fact, some people with MTHFR mutations might potentially benefit from NAD+ supplementation as it supports mitochondrial function and cellular energy production without directly interfering with methylation cycles. However, as with any supplement, start with a lower dose (typically 100-250mg daily) and monitor for any adverse reactions. Some individuals report mild side effects like flushing, headaches, or digestive discomfort when taking NAD+ supplements. If you have MTHFR mutations, you're likely already addressing methylation support through other means such as methylfolate or methylcobalamin supplementation, which can be continued alongside NAD+ supplementation. As always, consulting with a healthcare provider familiar with both MTHFR mutations and NAD+ supplementation would be ideal before starting any new supplement regimen, especially if you have existing health conditions or take medications 1, 2, 3, 4, 5.
Key considerations for individuals with MTHFR gene mutations taking NAD+ peptides include:
- Monitoring for adverse reactions
- Starting with a lower dose
- Continuing methylation support through other means
- Consulting with a healthcare provider before starting NAD+ supplementation The relationship between MTHFR gene mutations and homocysteine levels has been studied extensively, with some studies suggesting that MTHFR polymorphisms may be associated with increased cardiovascular risk 2, 4, 5. However, the impact of NAD+ supplementation on homocysteine levels and cardiovascular risk in individuals with MTHFR gene mutations is not well established and requires further research. In the context of renal disease, some studies have suggested that the C677T mutation of MTHFR may be associated with cardiovascular disease prevalence 5. Overall, while there is no significant issue with taking NAD+ peptides if you have MTHFR gene mutations, individual responses may vary, and careful monitoring and consultation with a healthcare provider are recommended.