Availability of Adsorption Filters for CRRT
This question cannot be answered from the medical literature provided, as availability of specific CRRT equipment is determined by local supply chains, regulatory approvals, hospital purchasing agreements, and regional distribution networks—not by clinical guidelines or research evidence.
What the Evidence Actually Addresses
The provided evidence discusses the clinical use and efficacy of adsorption-based therapies in CRRT, but does not address procurement, availability, or ease of access in any geographic location 1, 2.
Clinical Context of Adsorption in CRRT
Adsorption is recognized as a mechanism for solute removal during CRRT, particularly for middle and large molecular weight substances, though its clinical relevance remains uncertain 1.
Sorbent hemoperfusion (adsorption-based therapy) is being applied more broadly in critically ill patients, especially those with sepsis and systemic inflammation, representing an evolution in CRRT technology over the past 40 years 2.
High adsorptivity filters are mentioned as requiring further research regarding their effects on middle/large molecule removal, but specific recommendations about their use cannot be made based on current evidence 1.
Adsorptive clearance appears to have minimal impact on overall solute removal in standard CRRT, with median time-weighted average adsorptive clearance of beta-2 microglobulin showing negligible contribution 3, 4.
What You Need to Do Instead
To determine availability and ease of procurement in your specific location, you must:
- Contact CRRT equipment manufacturers directly (e.g., Baxter, Fresenius, Nikkiso) to identify authorized distributors in your region
- Consult your hospital's procurement or supply chain department regarding existing contracts and ordering processes
- Check with local nephrology or critical care professional societies for information on regional availability
- Contact neighboring tertiary care centers to learn about their experience obtaining these devices
Important Clinical Caveat
Resource-limited settings face significant barriers to initiating and sustaining CRRT programs, including limited resources, lack of technical support, cost, and administrative issues—challenges that extend to specialized equipment like adsorption filters 5.