From the Research
For IVIG administration, it is recommended to use PVC-free tubing to minimize the risk of DEHP nanodroplets leaching into the solution and promoting IVIG aggregation and complement activation, as supported by the most recent study 1. When administering IVIG, it is crucial to prioritize the use of appropriate tubing materials to ensure patient safety and maintain the integrity of the immunoglobulin product. The study published in 2020 1 highlights the potential risks associated with using PVC IV bags, which can release DEHP nanodroplets into the solution, leading to IVIG aggregation and complement activation. Key considerations for IVIG administration include:
- Using a dedicated IV administration set with an in-line filter, typically 0.2-0.22 micron in size
- Ensuring the tubing is compatible with an infusion pump for precise rate control
- Priming the tubing with the IVIG solution itself rather than saline to ensure accurate dosing
- Checking the manufacturer's guidelines for specific tubing material requirements, such as PVC-free tubing, for certain IVIG formulations By following these guidelines and using PVC-free tubing, healthcare professionals can minimize the risk of adverse reactions and ensure the safe and effective administration of IVIG.