From the Guidelines
Tirzepatide is not recommended to be dosed 3 times a week, as the standard dosing frequency is once weekly.
Dosing Frequency and Side Effects
- The recommended dosing frequency of Tirzepatide is once weekly, with typical adult maintenance doses of 5 mg, 10 mg, or 15 mg 1.
- Common side effects of Tirzepatide include gastrointestinal side effects, injection site reactions, elevated heart rate, and hypoglycemia 1.
- Possible safety concerns and considerations include pancreatitis, acute kidney injury, cholelithiasis, and gallstone-related complications 1.
Important Considerations
- The dose of Tirzepatide should be used with caution in people with kidney disease, and discontinued if pancreatitis is suspected 1.
- Patients using oral hormonal contraception should be advised to use or add a non-oral contraception method for 4 weeks after initiation and dose escalations 1.
From the Research
Dosing Frequency of Tirzepatide
- The recommended dosing frequency of Tirzepatide is once a week, not three times a week 2, 3, 4, 5.
- The studies suggest that Tirzepatide is administered subcutaneously once a week, with doses ranging from 5 to 15 mg 2, 3, 4, 5.
- There is no evidence to support the administration of Tirzepatide three times a week 2, 3, 6, 4, 5.
Administration and Dosage
- Tirzepatide is administered subcutaneously once a week, with the dose titrated to achieve optimal efficacy and tolerability 2, 3, 5.
- The mean dose of weekly Tirzepatide at 3 months was 5.6 mg, which increased to 9.7 mg at 1 year in one study 6.
- The doses of Tirzepatide used in clinical trials were 5,10, and 15 mg once a week 3, 4, 5.