What are the benefits of taking creatine (creatine monohydrate) supplements?

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Last updated: February 12, 2025View editorial policy

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From the Guidelines

Creatine supplements have several benefits, including improving high-intensity repeated sprint performance, enhancing training capacity and chronic training adaptations, and potentially supporting brain function.

Benefits of Creatine Supplements

  • Improves high-intensity repeated sprint performance, as evidenced by the UEFA expert group statement on nutrition in elite football 1
  • Enhances training capacity and chronic training adaptations, such as increasing muscle strength and power and lean body mass 1
  • May also support brain function, although the exact mechanisms and benefits are not fully understood 1
  • Increases muscle creatine stores, leading to increased resynthesis of phosphocreatine, which is essential for high-intensity, short-duration activities 1

Important Considerations

  • Potential for 1-2 kg body mass increase after creatine loading, which may be a concern for some athletes 1
  • Individual response to creatine supplements may vary, and they should be trialled and monitored in training before being used in competition 1
  • The evidence for creatine supplements is stronger than for other performance supplements, such as β-alanine and nitrate 1

From the Research

Benefits of Creatine Supplementation

The benefits of taking creatine monohydrate supplements include:

  • Improved high-intensity exercise performance leading to greater training adaptations 2
  • Enhanced post-exercise recovery, injury prevention, thermoregulation, rehabilitation, and concussion and/or spinal cord neuroprotection 2
  • Potential benefits in preventing and/or reducing the severity of injury, enhancing rehabilitation from injuries, and helping athletes tolerate heavy training loads 2
  • Improved muscle mass, performance, and recovery in athletes and exercising individuals 3
  • Beneficial effects in older and patient populations, including improved physical and cognitive performance 3, 4
  • Potential therapeutic benefits in various clinical populations, such as:
    • Neurodegenerative diseases (e.g., muscular dystrophy, Parkinson's, Huntington's disease) 2, 4, 5
    • Diabetes, including improved glucose metabolism and insulin sensitivity 6
    • Osteoarthritis, fibromyalgia, aging, brain and heart ischemia, adolescent depression, and pregnancy 2
    • Muscle wasting in conditions such as sarcopenia and cachexia 4
    • Cardiovascular diseases, including improved exercise capacity 4
    • Chronic fatigue syndrome, including enhanced energy metabolism 4
    • Traumatic brain injury, including promoted brain energy metabolism and reduced neuronal damage 4

Safety and Tolerability

Creatine supplementation is generally considered safe and well-tolerated in healthy individuals and in a number of patient populations, with recommended dosages of 3-5 g/day or 0.1 g/kg of body mass/day 2, 3. However, it is essential to follow proper dosing to minimize potential adverse effects that may arise from chronic ingestion of excessively high doses 4.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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