What are the benefits of creatine (creatine monohydrate) supplementation in women?

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Last updated: February 12, 2025View editorial policy

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From the Research

Benefits of Creatine Supplementation in Women

  • Creatine monohydrate supplementation may help alleviate fatigue-related symptoms associated with the menstrual cycle, particularly during the early follicular and luteal phases 1
  • Supplementation can improve physical performance, cognitive function, and overall health in women by addressing creatine deficiencies, improving energy metabolism, and supporting recovery from physical and neurological challenges 1
  • Creatine supplementation appears to be effective for improving strength and exercise performance in pre-menopausal females 2
  • Post-menopausal females may experience benefits in skeletal muscle size and function when consuming high doses of creatine (0.3 g·kg-1·d-1) 2
  • Creatine supplementation may have favorable effects on bone when combined with resistance training in post-menopausal females 2
  • Pre-clinical and clinical evidence indicates positive effects from creatine supplementation on mood and cognition, possibly by restoring brain energy levels and homeostasis 2

Safety and Efficacy of Creatine Supplementation

  • Accumulating evidence suggests that creatine supplementation produces a variety of beneficial effects in older and patient populations, and is relatively well tolerated, especially at recommended dosages (i.e. 3-5 g/day or 0.1 g/kg of body mass/day) 3
  • Studies have consistently shown that creatine supplementation increases intramuscular creatine concentrations, which may help explain the observed improvements in high intensity exercise performance leading to greater training adaptations 4
  • Short and long-term supplementation (up to 30 g/day for 5 years) is safe and well-tolerated in healthy individuals and in a number of patient populations ranging from infants to the elderly 4

Specific Studies on Women

  • A 2-year, randomized, placebo-controlled trial found that creatine supplementation (3 g/d) did not improve bone health in older, postmenopausal women with osteopenia 5
  • However, another study found that creatine supplementation may be effective for improving strength and exercise performance in pre-menopausal females, and may have favorable effects on bone when combined with resistance training in post-menopausal females 2

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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