From the Research
Creatine Supplementation and Dementia Prevention in Women
- There is evidence to suggest that creatine supplementation may be beneficial for brain health, including cognitive processing and recovery from trauma 1.
- A study on female rats found that creatine supplementation ameliorated spatial learning and memory deficits induced by lipopolysaccharide (LPS), a model of mild cognitive impairment (MCI) 2.
- Creatine supplementation has been shown to upregulate mTORC1 signaling and markers of synaptic plasticity in the dentate gyrus, which may contribute to its neurocognitive effects 2.
- A narrative review suggests that creatine supplementation may offer benefits for women, including alleviating fatigue-related symptoms associated with the menstrual cycle and improving cognitive function 3.
- A study on older adults found that creatine supplementation improved cognitive processing, particularly in individuals with impaired cognitive function due to aging or sleep deprivation 4.
- A systematic review and meta-analysis found that creatine supplementation improved measures of memory in healthy individuals, particularly in older adults (66-76 years) 5.
Key Findings
- Creatine supplementation may have neurocognitive benefits, including improved cognitive processing and memory performance 1, 2, 4, 5.
- The optimal creatine protocol for increasing brain creatine levels and improving cognitive function is still to be determined 1.
- Creatine supplementation may be particularly beneficial for older adults and individuals with impaired cognitive function 4, 5.
- More research is needed to fully understand the effects of creatine supplementation on brain health and dementia prevention in women 1, 2, 3, 4, 5.