Clarification Needed: No "Keto-CTA" Study Exists
I cannot find any study called "Keto-CTA" (Ketoconazole-Computed Tomography Angiography) in the medical literature provided or in established medical research. This appears to be either a misnamed study or a conflation of unrelated medical terms.
Possible Interpretations
If You Mean CTA (CT Angiography) Studies:
The evidence provided discusses CTA performance characteristics across multiple clinical scenarios, but none involve ketoconazole:
For Lower Gastrointestinal Bleeding:
- CTA demonstrates 90% sensitivity and 92% specificity for detecting lower GI bleeding, with ability to identify bleeding rates as slow as 0.3 mL/min 1
- CTA identified active bleeding or potential bleeding lesions in 92% of cases versus only 29% identified by transcatheter arteriography 1
- Negative CTA in hemodynamically stable patients indicates conservative management can be safely initiated, with approximately 75% settling spontaneously 1
For Acute Mesenteric Ischemia:
- CTA should be performed without delay in any patient with suspected acute mesenteric ischemia, as every 6 hours of diagnostic delay doubles mortality 1
- Sensitivity ranges from 93-100% with specificity of 97.9-100% for detecting mesenteric ischemia 1
For Giant Cell Arteritis:
- CTA shows 67-73% sensitivity and 85-98% specificity for GCA diagnosis, though it is not recommended as first-line imaging 2
- CTA demonstrates high concordance with FDG-PET/CT (kappa: 0.64-1) for detecting GCA 1, 2
If You Mean Ketoconazole Studies:
The evidence discusses ketoconazole's safety profile and hepatotoxicity risk, but these are completely unrelated to CTA imaging:
- In drug interaction studies with 2,355 participants, only 1.7% had elevated liver transaminases with no deaths reported 3
- When used as antifungal treatment (median 276 days), 5.6% of patients developed elevated liver enzymes 3
- Symptomatic hepatic injury occurs in approximately 1 in 15,000 exposed individuals 4
Request for Clarification
Please provide the correct study name or clarify what specific clinical question you are asking about. The term "Keto-CTA" does not exist in medical literature as a recognized study or diagnostic modality.