What is the name of the extended-release (ER) version of guanfacine (Intuniv)?

Extended-Release Guanfacine Brand Name

The extended-release version of guanfacine is called Intuniv. 1

Key Distinguishing Features

• Intuniv is NOT interchangeable with immediate-release guanfacine on a mg-for-mg basis due to different pharmacokinetics, requiring separate dosing considerations 2

• The extended-release formulation provides once-daily dosing with "around-the-clock" symptom control, unlike immediate-release formulations that require multiple daily doses 3, 4

• Intuniv is FDA-approved specifically for ADHD treatment in children and adolescents aged 6-17 years, with dosing ranging from 1-7 mg/day depending on age and weight 1, 2, 5

Clinical Context

• The American Academy of Pediatrics specifically identifies extended-release guanfacine (Intuniv) as a non-stimulant medication with no abuse potential, making it particularly useful in adolescents at risk for medication diversion 1

• Evening administration is generally preferable to minimize daytime somnolence and fatigue, which are the most common adverse effects occurring in approximately 50% of patients 3, 6

• Therapeutic effects require 2-4 weeks before clinical benefits become apparent, unlike stimulants which work immediately 3, 4

Important Safety Consideration

• Intuniv must be tapered rather than abruptly discontinued (by 1 mg every 3-7 days) to avoid rebound hypertension and withdrawal effects 3, 4, 7