Laboratory and Diagnostic Testing for Vertigo
For a patient experiencing spinning sensations with closed eyes (vertigo), the initial diagnostic approach should prioritize clinical history, physical examination with positional testing (Dix-Hallpike maneuver), and audiometry, while reserving advanced vestibular function testing only for unclear or atypical presentations. 1
Essential First-Line Tests
Clinical Assessment and Positional Testing
- Dix-Hallpike testing is the primary diagnostic maneuver for benign paroxysmal positional vertigo (BPPV), which accounts for 85-95% of positional vertigo cases 1
- Supine roll test evaluates lateral (horizontal) canal BPPV, which represents 5-15% of BPPV cases 1
- Physical examination should include assessment of nystagmus patterns, gait, and balance 1
Audiometric Testing
- Audiogram is mandatory when assessing any patient with vertigo to identify Ménière's disease or other otologic causes 1
- Audiometry helps distinguish between peripheral vestibular disorders with and without hearing loss 1
When Advanced Vestibular Testing Is Appropriate
Indications for ENG/VNG Testing
Advanced vestibular function testing (electronystagmography or videonystagmography) should NOT be routinely ordered but is appropriate when: 2
- Diagnosis remains unclear after clinical examination
- Clinical presentation is atypical for common vestibular disorders
- Positional testing elicits equivocal or unusual nystagmus patterns
- Additional symptoms suggest CNS or otologic disorders beyond typical vestibular presentations
- Multiple concurrent peripheral vestibular disorders are suspected
- Patients remain symptomatic following standard treatment
Components of Comprehensive Vestibular Testing
When indicated, comprehensive testing includes: 1, 2
- Electronystagmography (ENG) or Videonystagmography (VNG): Records nystagmus in response to caloric stimulation, voluntary eye movements, and positional changes
- Vestibular caloric testing: Assesses horizontal semicircular canal function
- Video Head Impulse Test (vHIT): Evaluates high-frequency vestibulo-ocular reflex function 2
- Vestibular Evoked Myogenic Potentials (VEMP): Assesses otolith organ function (saccule and utricle) 2
Tests That Should NOT Be Routinely Ordered
Unnecessary Testing for Clear Diagnoses
- Do not routinely order vestibular function testing to establish the diagnosis of BPPV when diagnostic criteria are met through clinical examination 1, 2
- Do not routinely order vestibular function testing for Ménière's disease with typical history and symptoms 1, 2
- Routine blood tests (complete blood count, serum chemistry) are not indicated unless systemic disease is suspected 1
Imaging Considerations
- MRI of internal auditory canal and posterior fossa may be offered only in patients with non-fluctuating sensorineural hearing loss, tinnitus, or pressure when symptoms are not better accounted for by another disorder 1
- Routine CT or MRI is not indicated for typical BPPV or clear peripheral vestibular disorders 1
Critical Pitfalls to Avoid
Common Testing Errors
- Unnecessary vestibular testing leads to delays in diagnosis and treatment and increases costs without improving outcomes 2
- Normal vestibular test results do not rule out vestibular disorders, particularly Ménière's disease, where test results fluctuate throughout the disease course 2
- The degree of vestibular damage detected on testing correlates poorly with patient-perceived disability 2
- Ordering comprehensive testing for straightforward BPPV delays effective treatment with canalith repositioning procedures 1
Testing Discomfort
- Vestibular function testing can cause significant patient discomfort, including nausea and vertigo during the procedure 2
- This reinforces the importance of reserving such testing only for clinically appropriate situations
Algorithmic Approach to Testing
Step 1: Perform clinical history focusing on triggers (positional vs. spontaneous), timing (seconds vs. hours), and associated symptoms (hearing loss, tinnitus) 1
Step 2: Conduct Dix-Hallpike and supine roll testing to diagnose BPPV 1
Step 3: Obtain audiogram in all patients with vertigo 1
Step 4: If diagnosis is clear (typical BPPV or Ménière's disease), proceed directly to treatment without additional testing 1, 2
Step 5: Reserve ENG/VNG and comprehensive vestibular testing only for atypical presentations, failed treatment, or when diagnosis remains unclear after initial evaluation 2, 3