From the Guidelines
The most effective approach to improving erectile function is through the use of FDA-approved oral phosphodiesterase type 5 inhibitors (PDE5i), such as sildenafil, tadalafil, vardenafil, and avanafil, as they have been extensively studied and proven to be effective in the treatment of erectile dysfunction 1. When considering supplements, it's essential to prioritize those with the most substantial evidence supporting their efficacy.
- L-arginine, typically taken at 1500-5000mg daily, is a promising option as it increases nitric oxide production, relaxing blood vessels and improving blood flow to the penis.
- Other beneficial supplements include Panax ginseng (900-1000mg daily), zinc (25-45mg daily), vitamin D (1000-2000 IU daily), and horny goat weed (500-1000mg daily), which may enhance erectile function through various mechanisms. However, it's crucial to note that the evidence for these supplements is not as strong as that for PDE5i, and their effectiveness may vary from person to person 1. The American College of Physicians recommends that clinicians initiate therapy with a PDE-5 inhibitor in men who seek treatment for erectile dysfunction and who do not have a contraindication to PDE-5 inhibitor use, as this approach has been shown to demonstrate statistically significant and clinically relevant improvements in sexual intercourse and erectile function in patients with ED 1. Ultimately, the best approach to improving erectile function involves a combination of lifestyle improvements, such as regular exercise, healthy diet, stress management, and adequate sleep, alongside medical treatment, if necessary, under the guidance of a healthcare provider.
From the Research
Supplements for Erections
- L-citrulline has been shown to improve erection hardness in men with mild erectile dysfunction, with 50% of men experiencing an improvement in erection hardness score from 3 to 4 after taking L-citrulline 1.5 g/d for a month 2.
- L-arginine has been found to be effective in improving erectile function, with studies showing that it can increase nitric oxide production and improve blood flow to the penis 3, 4, 5.
- A systematic review of ingredients in popular male testosterone and erectile dysfunction supplements found that 19% of ingredients received an A grade for strong positive evidence, while 68% received C or D grades for contradicting, negative, or lacking evidence 3.
- Combination therapy with L-arginine and phosphodiesterase type 5 inhibitors (such as sildenafil or tadalafil) has been shown to be more effective than monotherapy for the treatment of erectile dysfunction 4, 5.
Key Ingredients
- L-citrulline: improves erection hardness in men with mild erectile dysfunction 2.
- L-arginine: increases nitric oxide production and improves blood flow to the penis 3, 4, 5.
- Tribulus, Eurycoma longifolia, Zinc, Aspartate, Horny goat weed, and Yohimbine: common ingredients in testosterone and erectile dysfunction supplements, but with limited evidence for their effectiveness 3.
Treatment Options
- Phosphodiesterase type 5 inhibitors (such as sildenafil or tadalafil): effective for the treatment of erectile dysfunction, but may have side effects 4, 6, 5.
- L-arginine and L-citrulline supplements: may be effective for improving erectile function, but more research is needed to confirm their efficacy and safety 2, 3, 4, 5.