What is the trade name of vaginal progesterone (Progesterone)?

Trade Names of Vaginal Progesterone

The most commonly used vaginal progesterone formulations are Crinone 8% gel (containing 90 mg progesterone) and micronized progesterone capsules such as Prometrium (200 mg), which can be used vaginally off-label. 1

Available Formulations

Crinone 8% Gel

• Contains 90 mg of micronized progesterone in a polycarbophil-based gel preparation 2, 3
• Administered once or twice daily depending on indication 2
• Manufactured by Fleet Laboratories Ltd. 3

Micronized Progesterone Capsules (Prometrium)

• Available in 100 mg and 200 mg strengths 4
• Originally formulated for oral use but commonly used vaginally off-label 1
• Contains micronized progesterone in peanut oil with gelatin capsule 4
• When used for short cervix, typically administered as 200 mg suppository daily 1

Utrogestan

• Available as 100 mg vaginal capsules 3
• Manufactured by Laboratories Besins International 3
• Typically dosed as 200 mg (two 100 mg capsules) three times daily 3

Clinical Guideline Recommendations

For prevention of preterm birth in women with short cervix (≤20 mm), either 90-mg vaginal progesterone gel or 200-mg micronized progesterone suppository daily is recommended from diagnosis until 36 weeks. 1

Important Caveat

• Use of vaginal progesterone for short cervix indication is currently off-label and requires patient counseling 1
• Both formulations (90 mg gel and 200 mg capsules) have been studied in randomized trials with demonstrated efficacy 1