Injectable Ornidazole Adult Dosing
The standard adult intravenous dose of ornidazole is 500 mg administered twice daily, typically given as an infusion over 20-60 minutes. 1
Standard Dosing Regimen
- 500 mg IV twice daily is the established dose for treating mixed aerobic-anaerobic infections and protozoal infections in adults 1
- The infusion should be administered over an appropriate timeframe (typically 20-60 minutes) to minimize infusion-related reactions 1
- Treatment duration is typically 5 days for acute gastrointestinal infections, though this may be extended based on clinical response 1
Clinical Context and Efficacy
- When combined with ofloxacin (200 mg) in fixed-dose combination infusions, ornidazole 500 mg twice daily demonstrated excellent efficacy in managing acute diarrhea and dysentery, with 98.43% of patients showing good to excellent response 1
- The combination significantly reduced watery stools from 9.3 to 1.4 per day and normalized body temperature within the treatment period 1
Tolerability Profile
- Ornidazole infusion is generally well-tolerated, with 98.43% of patients reporting good to excellent tolerability 1
- Minor adverse effects include:
- No serious adverse events requiring treatment discontinuation were reported in clinical studies 1
Important Clinical Considerations
- Avoid alcohol consumption during treatment and for at least 48 hours after the last dose, as nitroimidazoles can cause a disulfiram-like reaction
- Monitor for neurological symptoms with prolonged use, as nitroimidazoles have been associated with peripheral neuropathy at high cumulative doses
- Dose adjustment may be necessary in patients with severe hepatic impairment, though specific guidelines are not well-established