From the Research
I strongly advise against using monobenzone for skin depigmentation without medical supervision, and treatment duration should be individualized based on response, typically ranging from months to years until desired depigmentation is achieved, as supported by the study published in 2012 1. When prescribed by dermatologists, monobenzone, also known as benoquin, is a permanent depigmenting agent typically used only for extensive vitiligo cases where repigmentation is not feasible.
- The standard concentration is usually 20% cream applied twice daily to affected areas.
- Patients should understand that monobenzone causes irreversible destruction of melanocytes, resulting in permanent skin lightening that cannot be reversed.
- Side effects include skin irritation, contact dermatitis, and increased sun sensitivity.
- Additionally, depigmentation can occur in areas distant from application sites. This medication requires strict sun protection measures, including broad-spectrum sunscreen, protective clothing, and sun avoidance. Due to its permanent effects and potential complications, monobenzone should only be used under dermatologist supervision for specific medical conditions, not for cosmetic purposes. Other treatment options, such as narrowband UVB phototherapy, have shown efficacy in treating vitiligo, as demonstrated in studies published in 2020 2, 2009 3, 2007 4, and 2006 5, but monobenzone's use is limited due to its potent and permanent nature.