Dolomed and Leg Numbness
There is no evidence that Dolomed (diflunisal) causes numbness in the leg. Diflunisal is a non-steroidal anti-inflammatory drug (NSAID) with a well-established safety profile, and peripheral neuropathy or numbness is not a recognized adverse effect of this medication 1, 2.
Understanding the Medication
Diflunisal (Dolomed) is an aspirin derivative used primarily for pain relief and anti-inflammatory effects in conditions like rheumatoid arthritis and osteoarthritis 1, 2. The documented side effects are predominantly gastrointestinal in nature, with no reports of neurological symptoms such as numbness or tingling 1, 2.
Alternative Causes to Consider
If you are experiencing leg numbness while taking Dolomed, the symptom is almost certainly unrelated to the medication itself. You should be evaluated for other causes of leg numbness, which include:
Diabetic Neuropathy
- Presents with numbness, tingling, and pain in a "stocking-and-glove" distribution, typically starting in the feet 3
- Assessment should include evaluation of pinprick sensation, temperature perception, and vibration sense using a 128-Hz tuning fork 3
- Current symptoms of neuropathy include pain, burning, and numbness in the lower extremities 3
Peripheral Neuropathy from Other Causes
- Vitamin deficiencies, thyroid dysfunction, and toxic exposures can cause bilateral leg numbness 4
- Certain medications (not including diflunisal) can cause peripheral neuropathy, particularly chemotherapy agents and some disease-modifying drugs 3, 5
- Diabetes, older age, and concurrent use of other neurotoxic medications increase risk for neuropathy 5
Spinal Pathology
- Cervical or lumbar spine disease can cause radiating numbness in the legs 3
- "Alarm symptoms" requiring urgent evaluation include decreased leg strength, difficulty controlling the legs, wobbly gait, and numbness radiating from the groin or legs 3
Critical Action Steps
If you are experiencing leg numbness:
- Do not assume it is related to Dolomed - this medication does not cause peripheral neuropathy 1, 2
- Seek medical evaluation to identify the actual cause, particularly if you have diabetes, as screening for diabetic neuropathy should occur at least annually 3
- Report any additional symptoms such as weakness, pain, or difficulty walking, as these may indicate more serious conditions requiring urgent assessment 3
- Consider whether you are taking any other medications known to cause neuropathy, or have risk factors such as diabetes or vitamin deficiencies 4, 5