Peridex (Chlorhexidine Gluconate 0.12%) Dosing
The standard dosing for Peridex is 15 mL of undiluted 0.12% chlorhexidine gluconate oral rinse, used twice daily (morning and evening) for 30 seconds after toothbrushing. 1
Standard Dosing Regimen
- Volume per use: 15 mL (½ fluid ounce) of undiluted solution 1
- Frequency: Twice daily—once in the morning and once in the evening 1
- Duration of rinse: 30 seconds per application 1
- Timing: Administer after toothbrushing 1
Administration Instructions
- Do not dilute the solution before use 1
- Do not rinse with water or other mouthwashes immediately after use 1
- Do not brush teeth immediately after rinsing 1
- Do not eat immediately after use 1
- Expectorate (spit out) the rinse after the 30-second rinse period—Peridex is not intended for ingestion 1
Clinical Context
- Initiation timing: Therapy should begin directly following a dental prophylaxis 1
- Re-evaluation schedule: Patients should receive a thorough prophylaxis at intervals no longer than 6 months 1
- Primary indication: Treatment and prevention of gingivitis in patients with established periodontal disease 1, 2
Alternative Dosing Considerations
While the FDA-approved dosing is 0.12% twice daily, international guidelines note that a 0.2% concentration used twice daily is standard in some countries (such as the UK for specific conditions like Stevens-Johnson syndrome management) 3. However, for standard gingivitis treatment in the United States, the 0.12% formulation at 15 mL twice daily remains the recommended dose 1.
Common Pitfalls to Avoid
- Staining: The most frequently reported side effect is staining of teeth, restorations, and tongue, which occurs in the majority of patients 4
- Taste alterations: Some patients experience bitter taste, which may affect compliance 4
- Dilution error: Do not dilute the 0.12% formulation unless specifically directed for special circumstances (such as reducing soreness in severely inflamed mucosa) 3