Generic Name of Simipex
The generic name of Simipex is pramipexole dihydrochloride. 1
Medication Details
Pramipexole is a nonergot dopamine agonist with high specificity for D2 subfamily dopamine receptors, particularly showing preferential affinity for D3 receptor subtypes. 1
Chemical Composition
- The chemical name is (S)-2-amino-4,5,6,7-tetrahydro-6-(propylamino) benzothiazole dihydrochloride monohydrate 1
- Molecular formula: C10H17N3S · 2HCl · H2O with molecular weight of 302.27 1
- Available as pramipexole dihydrochloride monohydrate in tablet form 1
Available Strengths
Pramipexole tablets are available in 0.125 mg, 0.25 mg, 0.5 mg, 1 mg, and 1.5 mg strengths. 1 Your current prescription of "Simipex 0.25 TAB 250mcg" corresponds to the 0.25 mg (250 mcg) strength.
Approved Indications
- Treatment of signs and symptoms of idiopathic Parkinson's disease 1, 2
- Treatment of moderate-to-severe primary restless legs syndrome (RLS) 3, 2
Key Pharmacokinetic Properties for Restless Leg Syndrome Management
- Bioavailability exceeds 90%, with peak concentrations reached in approximately 2 hours 1
- Terminal half-life is approximately 8 hours in young adults and 12 hours in elderly patients 1
- Steady-state concentrations are achieved within 2 days of consistent dosing 1
- For RLS, typical effective doses range from 0.25-0.75 mg once daily, with a mean optimal dose of 0.35 mg/day 4
Important Monitoring Parameters for Your Continued Use
- Blood pressure monitoring is essential due to risk of orthostatic hypotension, particularly in elderly patients 4
- Renal function should be monitored as pramipexole is 90% excreted unchanged in urine via renal tubular secretion 1
- Assess for augmentation symptoms (worsening of RLS symptoms, earlier onset, spread to other body parts) with long-term use 5
- Monitor for impulse control disorders including pathological gambling, hypersexuality, and compulsive shopping 5