What causes insomnia prior to the menstrual cycle (menstruation)?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: April 4, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Guidelines

Insomnia before your menstrual cycle can be effectively managed with cognitive behavioral therapy for insomnia (CBT-I) and relaxation strategies, as recommended by the American College of Physicians guideline 1. To address insomnia before your menstrual cycle, consider the following approaches:

  • Establish a consistent sleep schedule by going to bed and waking up at the same time daily, even on weekends, to help regulate your body's internal clock.
  • Practice relaxation techniques like deep breathing, meditation, or gentle yoga before bedtime to reduce stress and anxiety, which can contribute to insomnia.
  • Limit caffeine and alcohol consumption, particularly in the week before your period, as these substances can disrupt sleep patterns.
  • Consider taking magnesium supplements (300-400mg daily), especially magnesium glycinate, which may help improve sleep quality and reduce premenstrual syndrome (PMS) symptoms.
  • Over-the-counter options like melatonin (1-3mg taken 1-2 hours before bedtime) may help regulate your sleep cycle, but it is essential to consult with a healthcare provider before starting any new supplements. The American College of Physicians guideline 1 emphasizes the importance of psychological therapy, including CBT-I, as a first-line treatment for insomnia, and it is crucial to consult with a healthcare provider to determine the best course of treatment for your specific needs.

From the Research

Insomnia Before Menstrual Cycle

  • Insomnia is a highly prevalent disease among women, directly affecting performance and quality of life 2.
  • The female organism has its peculiarities due to hormonal changes, which can lead to an overload of work and stress, making women more vulnerable to insomnia 2.
  • Progesterone has an important effect on sleep, acting both as a hypnogenic and as a respiratory stimulant, and hormonal contraceptives may be a new therapeutic element for the treatment of insomnia 2.

Hormonal Changes and Sleep

  • The menstrual cycle influences stage 2 and REM sleep in women, irrespective of premenstrual dysphoric disorder (PMDD) 3.
  • Women with PMDD showed a decreased response to melatonin in their luteal phase as compared to the follicular phase of the menstrual cycle 3.
  • Sleep disturbance and decreased melatonin secretions due to hormonal fluctuations during the luteal phase of the menstrual cycle could explain the sleep complaints of PMDD 3.

Menstrual Cycle-Related Variation in Sleep

  • Sleep homeostasis and continuity remain stable across the menstrual cycle in young women, but the influence of the menstrual cycle on physiological sleep in midlife women is unknown 4.
  • Midlife women have more awakenings and arousals per hour of sleep and less percentage slow wave sleep when progesterone is raised during the luteal compared with the follicular phase 4.
  • Sleep is more disrupted in the luteal phase compared with the follicular phase in midlife women, whether or not they have an insomnia disorder 4.

Treatment of Insomnia

  • Trazodone has been shown to be effective in the treatment of insomnia, with evidence demonstrating its efficacy for primary insomnia, as well as secondary insomnia 5.
  • The use of hormonal contraceptives, mainly those based on progestagens, could be a new therapeutic element for the treatment of insomnia and improvement of women's sleep pattern and quality of life 2.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Sleep and Premenstrual Syndrome.

Journal of sleep medicine and disorders, 2016

Research

Trazodone for Insomnia: A Systematic Review.

Innovations in clinical neuroscience, 2017

Related Questions

What is the effect of a 450mg dose of trazodone?
What is the best course of action for a 68-year-old male (YOM) with insomnia who is currently taking 150-200mg of trazodone (trazodone) at hour of sleep (HS) and continues to experience insomnia and restless leg syndrome (RLS)?
What treatment should be started for a 69-year-old male with a history of insomnia, currently taking trazodone (trazodone) 50mg, residing in a long-term care facility, who expresses depression and a wish to die without suicidal ideation (SI) or homicidal ideation (HI)?
What is the best depression medication option for a 75-year-old female taking trazodone for insomnia?
In a 40-year-old man taking bupropion (Wellbutrin) 450 mg daily and trazodone 100 mg at night for depression and insomnia, should the bupropion be reduced to 300 mg and the trazodone increased?
What is the difference between Acute Coronary Syndrome (ACS) and gastroesophageal reflux disease (GERD)-related heartburn?
What is more important for building muscle, total testosterone or free testosterone?
Is gastroesophageal reflux disease (GERD) likely causing heartburn when stomach acid flows back up into the esophagus?
What is the treatment for lower extremity stab phlebectomy (surgical removal of varicose veins in the lower extremities)?
What is the pathophysiology and management of Hyperosmolar Hyperglycemic State (HHS), a condition characterized by severe hyperglycemia and impaired renal function?
What are the types of Syndrome of Inappropriate Antidiuretic Hormone (SIADH) secretion?

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.