Is Delsym (dextromethorphan) safe to use during breastfeeding?

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Last updated: December 5, 2025View editorial policy

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Dextromethorphan (Delsym) Safety During Breastfeeding

Delsym (dextromethorphan) is generally considered safe to use during breastfeeding, though you should consult a healthcare professional before use as recommended by the FDA drug label. 1

FDA Guidance

The FDA drug label for dextromethorphan specifically states: "If pregnant or breast-feeding, ask a health professional before use." 1 This indicates the medication is not contraindicated during breastfeeding, but warrants professional consultation before use.

Supporting Evidence for Safety

  • Most commonly used over-the-counter drugs, including cough medications, are relatively safe for breastfed infants, as the dose received via breast milk is generally small and much less than known safe doses given directly to infants. 2

  • Dextromethorphan has been on the market for many years and has never been implicated as causing harm in breastfeeding infants. 3

  • The general principle is that most medications appear in only small amounts in breast milk, and with proper guidance, mothers can safely continue breastfeeding while taking necessary medications. 4

Clinical Approach

When a breastfeeding mother needs cough suppression:

  • Weigh the risk of untreated maternal symptoms (persistent cough affecting rest and recovery) against the theoretical minimal risk of medication transfer through breast milk. 5

  • Women should not be discouraged from breastfeeding while taking compatible medications, given the substantial benefits of breastfeeding for both infant and maternal health. 5

  • Use the lowest effective dose for the shortest duration necessary to control symptoms. 4

Important Caveats

  • Monitor the infant for unusual sedation or changes in feeding patterns, though adverse effects from dextromethorphan in breastfed infants have not been reported in the literature. 2, 4

  • Avoid use if taking MAOIs or within 2 weeks of stopping MAOI therapy. 1

  • Stop use and consult a physician if cough persists beyond 7 days or returns with fever, rash, or persistent headache. 1

References

Research

Drugs in breastfeeding.

Australian prescriber, 2015

Research

Dextromethorphan. Extrapolation of findings from reproductive studies in animals to humans.

Canadian family physician Medecin de famille canadien, 1999

Research

Minimizing infant exposure to and risks from medications while breastfeeding.

The Journal of perinatal & neonatal nursing, 1997

Guideline

Mucinex Safety During Breastfeeding

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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