From the Guidelines
The 3DO weight loss program, resulting in an average weight loss of 10.4% of initial body weight, is a highly effective approach for improving health outcomes, including glycemia, blood pressure, and lipids, as supported by the most recent evidence from 2025 1.
Key Components of the Program
- Diet modification: a calorie-restricted diet (usually 1200-1500 calories per day for women and 1500-1800 for men)
- Increased physical activity: at least 150 minutes of moderate-intensity exercise weekly
- Behavioral changes: self-monitoring, stress management, and other strategies to build sustainable habits
Clinical Significance
The 10.4% weight reduction achieved through this program is clinically significant, as research shows that losing just 5-10% of body weight can substantially improve health markers, including blood pressure, cholesterol levels, and blood sugar control 1.
Long-term Maintenance
For successful long-term maintenance, participants should gradually transition to a balanced diet with slightly higher calories while maintaining regular physical activity and continuing behavioral strategies.
Evidence-Based Support
The effectiveness of this program is supported by recent studies, including a 2025 review of obesity management in adults, which highlights the importance of comprehensive, evidence-based treatment combining behavioral interventions, nutrition, physical activity, pharmacotherapy, and metabolic/bariatric procedures as appropriate for individual patients 1. Additionally, a 2025 standard of care in diabetes report emphasizes the benefits of sustained weight loss, including improved glycemia, blood pressure, and lipids, and reduced need for disease-specific medications 1.
From the Research
Weight Loss and 3do
- The provided studies do not directly address the topic of "3do weight loss 10.4%".
- However, some studies discuss the importance of nutrition and dietary management in relation to weight loss and overall health 2, 3, 4.
- A study on global, regional, and national prevalence of adult overweight and obesity forecasts that the total number of adults living with overweight and obesity will reach 3.80 billion by 2050, assuming the continuation of historical trends 5.
- Another study highlights the importance of dietary patterns for healthy aging, suggesting that diets rich in plant-based foods, with moderate inclusion of healthy animal-based foods, may enhance overall healthy aging 4.
Nutrition and Weight Loss
- Nutritional guidance is pivotal to reducing the risk of thyroid disease and to managing it when it arises, including the prescription of diets rich in micronutrients such as iodine, selenium, iron, zinc, and vitamins B12, D3, and A 2.
- Dietotherapy of Hashimoto's thyroiditis is based on the proper nourishment of the body and regulation of the immune system by an anti-inflammatory diet, and may involve eliminating lactose and gluten due to potential interactions with thyroid antigens 3.
- Higher intakes of fruits, vegetables, whole grains, unsaturated fats, nuts, legumes, and low-fat dairy products are linked to greater odds of healthy aging, whereas higher intakes of trans fats, sodium, sugary beverages, and red or processed meats are inversely associated 4.