From the Guidelines
DHEA supplements should be used with caution due to the potential risks of hormonal imbalances, worsening of hormone-sensitive conditions, and negative impacts on cholesterol levels and liver function, as noted in the 2024 NCCN guidelines 1. The use of DHEA supplements can lead to significant risks, including hormonal imbalances, as DHEA is converted into sex hormones like testosterone and estrogen in the body. This can result in acne, hair loss, facial hair growth in women, deepening of the voice, and mood changes including aggression or irritability.
- Key risks associated with DHEA supplements include:
- Worsening of hormone-sensitive conditions such as breast cancer, prostate cancer, endometriosis, and uterine fibroids
- Negative impacts on cholesterol levels by lowering HDL (good cholesterol) and potentially increasing cardiovascular risk
- Liver damage with long-term use
- Interactions with medications including antipsychotics, insulin, and drugs metabolized by the liver
- Common side effects such as oily skin, stomach upset, high blood pressure, and menstrual irregularities According to the 2024 NCCN guidelines, the safety data for the use of androgen-based therapy, including DHEA, in survivors of hormonally mediated cancers are limited, and vaginal DHEA should be used with caution in survivors receiving aromatase inhibitor therapy 1.
- It is essential to consider these risks and consult with a healthcare provider before using DHEA supplements, especially for individuals with hormone-sensitive conditions, liver disease, or those who are pregnant or breastfeeding.
From the Research
Risks of DHEA Supplements
- There is limited research on the risks of DHEA supplements, but some studies suggest that they may have negative effects on cardiovascular health 2.
- DHEA may increase the risk of cardiovascular disease, particularly in individuals with pre-existing conditions 2.
- However, other studies suggest that DHEA may have beneficial effects on cardiovascular health, such as reducing inflammation and improving blood vessel function 3, 2.
- The evidence on the risks and benefits of DHEA supplements is inconsistent, and more research is needed to fully understand their effects on human health.
Potential Interactions and Side Effects
- DHEA may interact with other medications, such as steroids, and increase the risk of side effects 3.
- High doses of DHEA may cause acne, hair loss, and other hormonal imbalances 3.
- The long-term effects of DHEA supplementation are not well understood, and more research is needed to determine their safety and efficacy.
Comparison to Other Health Factors
- A healthy diet and regular physical activity are important for maintaining cardiovascular health and reducing the risk of chronic diseases 4, 5.
- The ketogenic diet, which is high in fat and low in carbohydrates, may have negative effects on cardiovascular health, particularly in the long term 6.
- A plant-based diet, on the other hand, has been shown to reduce the risk of oncological and cardiovascular diseases and promote a prolonged life span 6.