What are the best lotions for treating psoriatic skin?

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Last updated: December 8, 2025View editorial policy

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Best Lotions for Psoriatic Skin

Emollients (moisturizers) are the essential foundation of psoriatic skin care and should be applied 1-3 times daily to all affected areas, with the American Academy of Dermatology recommending them as standard adjunctive therapy for all psoriasis patients. 1, 2

Primary Role of Emollients

Emollients work by retaining moisture in the stratum corneum, improving skin hydration and barrier function, which directly addresses the fundamental skin barrier dysfunction present in psoriasis. 2 They provide several critical benefits:

  • Reduce itching and scaling (desquamation), which are particularly problematic in excoriated plaque psoriasis 2
  • Prevent quick relapse when topical corticosteroids are discontinued 2
  • Enhance efficacy of active treatments - when combined with topical corticosteroids for 4-8 weeks, emollients improve outcomes by reducing itching, desquamation, and total body surface area involvement 2, 3
  • Steroid-sparing effect - one study demonstrated that water-in-oil cream or lotion combined with betamethasone dipropionate cream increased efficacy while achieving control with fewer steroid applications 1

Specific Evidence for Emollient Efficacy

An RCT showed that mometasone plus emollient improved the area of palmoplantar skin affected, desquamation, and symptoms compared with mometasone alone after 4 weeks of treatment. 2 This demonstrates that emollients provide measurable clinical benefit beyond active medications alone.

Practical Application Guidelines

  • Apply 1-3 times daily to affected areas 1, 2
  • Apply after bathing - a thin coat of petrolatum applied to psoriatic areas after bathing may be particularly beneficial 1
  • Use in conjunction with active treatments for 4-8 weeks 2, 3
  • Apply after active medications - when using calcipotriene/corticosteroid combinations, apply emollients afterward to avoid washing off active medication 3

Specialized Moisturizer Formulations

Ceramide-containing moisturizers show particular promise, with studies demonstrating overall improvement in skin appearance and providing relief for psoriasis. 4 Ceramides help restore the epidermal barrier function that is compromised in psoriatic skin.

Salicylic acid-containing moisturizers (typically 2-6%) soften plaques and enhance absorption of topical treatments such as corticosteroids. 5, 4 However, never combine salicylic acid with calcipotriene, as the acidic pH inactivates calcipotriene. 3

Safety Profile

  • No known contraindications unless hypersensitivity to ingredients exists 1, 2
  • Small risk of contact dermatitis with some formulations 2
  • Safe during pregnancy and lactation 1, 2, 3
  • Safe for pediatric use 1

Integration with Active Treatments

Emollients should be used as part of a rotational therapy approach with topical vitamin D analogues, topical calcineurin inhibitors, and topical corticosteroids as steroid-sparing regimens. 2 When used with topical calcipotriene, emollients may reduce irritation and enhance efficacy. 2

Common Pitfall to Avoid

The most significant error is viewing emollients as optional or secondary. Emollients represent an internationally accepted standard adjunctive therapeutic approach 1 and should be prescribed to every psoriasis patient regardless of disease severity or other treatments being used. Their barrier-restoring properties address fundamental pathophysiology, not just symptoms. 1, 4

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Emollient Therapy in Psoriasis Management

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Topical Treatment for Mild to Moderate Psoriasis

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Treatment of Itchy, Flaky Scalp Conditions

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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