From the Guidelines
Fatigue is a common side effect of Ozempic (semaglutide), and patients should be aware of this potential issue, as it is listed among the common side effects in the study published in 2023 1. When considering the management of Ozempic-related fatigue, it's essential to prioritize strategies that improve overall quality of life and minimize morbidity.
Key Considerations
- Staying well-hydrated is crucial, as mild dehydration can exacerbate fatigue.
- Maintaining adequate protein intake (0.8-1g per kg of body weight) can help support energy levels.
- Getting 7-9 hours of quality sleep is vital for managing fatigue.
- Regular moderate exercise can paradoxically improve energy levels, though it's essential to start gently if feeling exhausted.
Mechanism and Management
Ozempic causes fatigue through multiple mechanisms, including slowing gastric emptying, which can reduce nutrient absorption, and affecting glucose metabolism 1. If fatigue is severe or persists beyond 8 weeks, it's crucial to consult a healthcare provider, as dose adjustment may be necessary or there could be other underlying causes like anemia or thyroid issues that need investigation.
Important Reminders
- Never stop taking Ozempic without medical guidance, as this can lead to adverse effects on blood sugar control and weight management.
- The study published in 2023 1 provides valuable insights into the side effects of Ozempic, including fatigue, and highlights the importance of careful patient monitoring and management.
From the FDA Drug Label
Fatigue, Dysgeusia and Dizziness Other adverse reactions with a frequency of >0.4% were associated with OZEMPIC include fatigue, dysgeusia and dizziness.
Ozempic and Fatigue: Fatigue is listed as an adverse reaction associated with Ozempic, with a frequency of more than 0.4% 2.
From the Research
Ozempic Fatigue
- Ozempic, also known as semaglutide, is a medication used to treat type 2 diabetes and has been shown to have various effects on the body.
- There is limited direct evidence on Ozempic fatigue, but some studies suggest that semaglutide may have an impact on energy levels and fatigue.
- A study on vitamin B12 deficiency 3 found that fatigue can be a symptom of vitamin B12 deficiency, which may be related to the use of semaglutide.
- Another study on the effects of vitamin B12 supplementation on cognitive function, depressive symptoms, and fatigue 4 found that vitamin B12 supplementation had no significant effect on fatigue.
- Studies on oral semaglutide and cardiovascular outcomes in persons with type 2 diabetes 5, 6 did not specifically address fatigue as an outcome, but found that semaglutide was associated with a lower risk of major adverse cardiovascular events.
- A study on semaglutide and walking capacity in people with symptomatic peripheral artery disease and type 2 diabetes 7 found that semaglutide improved walking distance, but did not specifically address fatigue.
- Overall, while there is limited direct evidence on Ozempic fatigue, it is possible that semaglutide may have an impact on energy levels and fatigue, potentially through its effects on vitamin B12 levels or other mechanisms.