From the Research
Definition of DORA
- DORA stands for Dual Orexin Receptor Antagonist, a class of sleep aids that target the orexin system to promote sleep 1, 2, 3, 4, 5.
Mechanism of Action
- DORAs work by antagonizing the orexin receptors, specifically OX1 and OX2 receptors, which play a major role in arousal and sleep/wake cycles 5.
- This mechanism of action is distinct from traditional sleep aids, such as GABA receptor modulators, and may offer a more selective and safer alternative for the treatment of insomnia 3.
Examples of DORAs
- Daridorexant is a recently approved DORA for the treatment of insomnia, which has shown promising results in preclinical and clinical studies 1, 4.
- Other DORAs, such as suvorexant, have also been clinically tested and have shown efficacy in inducing and maintaining sleep 5.
Potential Benefits and Limitations
- DORAs may offer several benefits, including a lower risk of abuse, tolerance, and cognitive impairment compared to traditional sleep aids 1, 4.
- However, the ideal orexin agent to achieve a balanced increase in REM and non-REM sleep is still a topic of debate, and more research is needed to fully understand the effects of DORAs on sleep architecture 5.