From the FDA Drug Label
The FDA drug label does not answer the question.
From the Research
Candida epididymitis should be treated with oral antifungal medications, such as fluconazole, as the first line of treatment, considering the most recent and highest quality study available 1. The treatment of Candida epididymitis typically involves oral antifungal medications, with fluconazole being the most commonly recommended option.
- The dosage of fluconazole usually starts with 400 mg on the first day, followed by 200-400 mg daily for 2-4 weeks.
- For severe cases or fluconazole-resistant strains, alternatives such as voriconazole 200 mg twice daily or amphotericin B (0.5-1 mg/kg/day) intravenously may be considered.
- Supportive measures, including scrotal elevation, ice packs, and pain management with NSAIDs like ibuprofen 400-600 mg every 6-8 hours, are also important.
- Patients should be evaluated for underlying conditions that increase susceptibility to fungal infections, such as diabetes, immunosuppression, or recent antibiotic use, as noted in earlier studies 2, 3.
- Candida epididymitis is less common than bacterial forms and often occurs in immunocompromised patients or those with urinary tract abnormalities, highlighting the need for proper diagnosis and treatment, as discussed in 4 and 5.
- Diagnosis typically requires culture of epididymal aspirate or urine to identify the fungal pathogen, and follow-up is important to ensure resolution of the infection, with clinical improvement usually expected within 7-10 days of starting treatment.