What is the treatment for mononucleosis?

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Treatment of Infectious Mononucleosis

Treatment for infectious mononucleosis is primarily supportive care, as antiviral medications like acyclovir have no proven benefit in otherwise healthy individuals. 1, 2

Pharmacological Management

Antiviral Therapy

  • Acyclovir and other antiviral agents are not recommended for routine treatment of infectious mononucleosis in immunocompetent patients, as they do not ameliorate the clinical course 3, 1, 4
  • In immunosuppressed patients with severe primary EBV infection, ganciclovir or foscarnet may be considered despite lack of supporting evidence, though these agents are more toxic than acyclovir 3, 1

Corticosteroid Therapy

  • Corticosteroids should be reserved only for specific severe complications, particularly severe airway obstruction or pharyngeal edema requiring intervention 1, 2
  • Corticosteroids are not recommended for routine use and should be avoided unless benefits clearly outweigh potential risks 4, 2

Antibiotics

  • Avoid empirical antibiotic prescription without confirming bacterial superinfection 1
  • Ampicillin and amoxicillin should be specifically avoided, as they cause a characteristic rash in patients with infectious mononucleosis 1

Supportive Care Measures

Activity Modification

  • Bed rest should not be enforced; the patient's energy level should guide activity 2
  • Patients must avoid contact sports or strenuous exercise for at least 4 weeks after symptom onset to prevent splenic rupture 2
  • Some sources recommend extending this restriction to 8 weeks or until splenomegaly resolves 5

Symptomatic Treatment

  • Adequate hydration, analgesics, and antipyretics are the mainstays of supportive care 2
  • Antihistamines are not recommended for routine treatment 2

Management in Special Populations

Immunosuppressed Patients

  • Immunomodulator therapy should be reduced or discontinued if possible when primary EBV infection occurs in patients on immunosuppressive medications 3, 1
  • Specialist consultation is essential for investigation and management of immunocompromised patients with primary EBV infection 1
  • Careful clinical assessment is warranted with full blood count, blood film, liver function tests, and EBV serology for patients on thiopurine therapy 1

Severe Complications Requiring Intervention

  • Discontinuation of immunosuppressive therapy may result in spontaneous regression of EBV-associated lymphoproliferative disease 3
  • Biopsy diagnosis by a specialist hematopathologist is required to differentiate infectious mononucleosis from lymphoproliferative disease or lymphoma 3

Common Pitfalls and Caveats

  • Fatigue, myalgias, and need for sleep may persist for several months after acute infection resolves 2
  • Splenic rupture occurs in 0.1 to 0.5% of patients and is potentially life-threatening, making activity restriction critical 5
  • Most cases are mild to moderate in severity with full recovery over several weeks, though more severe cases occasionally require hospital admission 4

References

Guideline

Treatment of Infectious Mononucleosis

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Epstein-Barr virus infectious mononucleosis.

American family physician, 2004

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Infectious mononucleosis.

Australian family physician, 2003

Research

Infectious Mononucleosis: An Updated Review.

Current pediatric reviews, 2024

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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