What is the differential diagnosis for vomiting in a 3-month-old infant?

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Differential Diagnosis for Vomiting in a 3-Month-Old

Single Most Likely Diagnosis

  • Gastroesophageal reflux disease (GERD): This is a common condition in infants, characterized by the backflow of stomach contents into the esophagus, leading to vomiting. The symptoms often peak around 4 months of age, but can start as early as a few weeks old.

Other Likely Diagnoses

  • Viral gastroenteritis: This is a common cause of vomiting in infants, often accompanied by diarrhea and fever.
  • Overfeeding or feeding intolerance: Infants may vomit if they are overfed or have difficulty digesting certain formulas or breast milk.
  • Pyloric stenosis: Although less common, this condition, which involves narrowing of the pylorus (the passage between the stomach and small intestine), can cause projectile vomiting in infants, typically starting around 3 weeks of age.
  • Food allergy or intolerance: Allergies to proteins in formula or breast milk can cause vomiting, along with other symptoms like rash or diarrhea.

Do Not Miss Diagnoses

  • Intussusception: A condition where a part of the intestine slides into another, which can cause severe vomiting, abdominal pain, and bloody stools. It's a medical emergency.
  • Volvulus: A twisting of a portion of the intestine that can cut off blood flow, leading to severe vomiting, abdominal pain, and potentially life-threatening complications.
  • Hirschsprung's disease: A congenital condition affecting the large intestine, leading to severe constipation or intestinal obstruction, which can cause vomiting.
  • Inborn errors of metabolism: Certain metabolic disorders can present with vomiting, among other symptoms, and require prompt diagnosis and treatment to prevent serious complications.

Rare Diagnoses

  • Congenital anomalies of the gastrointestinal tract (e.g., esophageal atresia, duodenal atresia): These are rare conditions that can cause vomiting due to obstruction or other functional issues.
  • Neurological conditions (e.g., increased intracranial pressure, hydrocephalus): Although rare, neurological issues can cause vomiting in infants, often accompanied by other symptoms like lethargy, seizures, or abnormal head size.
  • Endocrine disorders (e.g., congenital adrenal hyperplasia): Certain endocrine conditions can lead to vomiting among a constellation of other symptoms, including electrolyte imbalances and failure to thrive.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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