What are the treatment options for Morton's neuroma?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: April 7, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Guidelines

Treatment for Morton's neuroma should begin with conservative approaches, prioritizing wide, comfortable shoes, custom orthotic inserts, and over-the-counter pain medications, as these methods can effectively reduce pressure and alleviate symptoms. According to the most recent and highest quality study 1, imaging techniques such as MRI can play a significant role in diagnostic and therapeutic decisions, with a sensitivity of 87% and specificity of 100% in evaluating patients with metatarsalgia and Morton's neuroma.

When considering treatment options, it is essential to prioritize methods that reduce pressure on the affected nerve and address inflammation and pain. Some key considerations include:

  • Wearing wide, comfortable shoes with a low heel and soft sole to reduce pressure on the affected nerve
  • Using custom orthotic inserts to redistribute weight and relieve pressure on the neuroma
  • Taking over-the-counter pain medications like ibuprofen (400-800mg three times daily) or naproxen (220-440mg twice daily) to reduce pain and inflammation
  • Icing the affected area for 15-20 minutes several times daily to decrease swelling
  • Modifying activities to avoid high-impact activities and those requiring tight footwear

For persistent symptoms, a podiatrist may administer a corticosteroid injection directly into the affected area, which can provide relief for weeks to months. However, it is crucial to note that local injections of corticosteroids are not recommended as an initial treatment option, as stated in the American College of Foot and Ankle Surgeons guidelines 1. If conservative treatments fail after 3-6 months, surgical options such as decompression or neurectomy may be considered, although these may result in permanent numbness in the affected toes.

From the Research

Treatment Options for Morton's Neuroma

  • Non-surgical interventions, such as corticosteroid or sclerosing injections, have been found to be effective in reducing pain and improving treatment success rates 2
  • Manipulation/mobilisation and extracorporeal shockwave therapy have also been reported to be effective in reducing pain 2
  • A comparative analysis of conservative versus surgical treatment of Morton's neuroma found that surgical excision may be the initial treatment of choice 3
  • A systematic review of the treatment of Morton's neuroma found that operative treatment had better outcomes than conservative treatment 4

Nonsurgical Treatments

  • Corticosteroid and local anaesthetic injection (CS+LA) may result in little to no difference in pain and function when compared with local anaesthetic injection (LA) alone 5
  • Ultrasound-guided (UG) CS+LA probably reduces pain and increases function when compared with non-ultrasound-guided (NUG) CS+LA 5
  • UG CS+LA may increase satisfaction compared with NUG CS+LA 5

Surgical Treatments

  • Plantar incision neurectomy (PN) may result in little to no difference for satisfaction and adverse events when compared with dorsal incision neurectomy (DN) 5
  • PN and DN have different adverse event profiles, with PN including hypertrophic scaring and foreign body reaction, and DN including missed nerve, artery resected, and wound infection 5

Evidence Quality

  • The evidence for the effectiveness of different treatments for Morton's neuroma is generally of low to moderate certainty 2, 5
  • Further high-quality randomised controlled trials are needed to confirm the results and establish a gold standard intervention 2, 4, 5

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

A comparative analysis of conservative versus surgical treatment of Morton's neuroma.

Journal of the American Podiatric Medical Association, 1989

Research

Treatment of Morton's neuroma: A systematic review.

Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons, 2018

Research

Treatments for Morton's neuroma.

The Cochrane database of systematic reviews, 2024

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.