What is the differential diagnosis for a 16-year-old female presenting with left-sided neck swelling, without fever, and normal temperature?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: April 7, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for 16 Year Old Female with Left Sided Neck Swelling

Single Most Likely Diagnosis

  • Benign neck cyst or thyroglossal duct cyst: This is a common cause of neck swelling in adolescents, often presenting as a painless, slowly enlarging mass. The absence of fever and systemic symptoms supports a benign etiology.

Other Likely Diagnoses

  • Lymphadenopathy due to viral or bacterial infection: Although the patient does not have a fever, lymphadenopathy can occur without systemic symptoms, especially in the context of a viral infection.
  • Thyroid nodule or goiter: Thyroid abnormalities can cause neck swelling and are relatively common in adolescents. A thyroid nodule or goiter could present unilaterally.
  • Branchial cleft cyst: These congenital anomalies can present as a neck mass, often becoming apparent during adolescence.

Do Not Miss Diagnoses

  • Malignant lymphoma: Although less common, lymphoma can present with lymphadenopathy and must be considered to ensure timely diagnosis and treatment.
  • Metastatic disease (e.g., from a head and neck primary): Rare in adolescents, but critical to diagnose early for effective management.
  • Tuberculosis lymphadenitis: Can present with neck swelling and may not always have systemic symptoms like fever, especially in its early stages.

Rare Diagnoses

  • Carotid body tumor: A rare, usually benign tumor that can cause neck swelling.
  • Paraganglioma: A rare neuroendocrine neoplasm that can occur in the neck.
  • Castleman disease: A rare lymphoproliferative disorder that can present with lymphadenopathy.

Each of these diagnoses has a different set of implications for management and prognosis, highlighting the importance of a thorough diagnostic workup.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.