From the Research
Duration of Post-Infectious Mononucleosis (IMN) Fatigue
- The duration of post-infectious mononucleosis (IMN) fatigue can vary, with some studies suggesting that it can last for several months 1, 2, 3, 4.
- One study found that 13% of adolescents met the criteria for chronic fatigue syndrome 6 months after infectious mononucleosis, while 7% and 4% met the criteria at 12 and 24 months, respectively 4.
- Another study reported that fatigue may be profound but tends to resolve within three months 5.
- A systematic review found that poor physical functioning, namely lengthy convalescence and being less fit or active, consistently predicted chronic ill health 2.
- A randomised controlled trial found that a brief psycho-educational intervention at the diagnosis of infectious mononucleosis may help prevent the development of chronic fatigue 3.
Factors Associated with Prolonged Fatigue
- Female gender and greater fatigue severity have been associated with the development of chronic fatigue syndrome in adolescents 4.
- Reduced levels of fitness and illness beliefs may be important predictors of fatigue following glandular fever 3.
- The use of steroid therapy during the acute phase of infectious mononucleosis did not increase the risk of developing chronic fatigue syndrome 4.
Recovery and Management
- Most patients with infectious mononucleosis have an uneventful recovery, with fatigue resolving within a few months 5.
- Treatment is mainly supportive, with reduction of activity and bed rest as tolerated recommended 5.
- Patients should be advised to avoid contact sports or strenuous exercise for 8 weeks or while splenomegaly is still present 5.