Treatment of Ruptured Tympanic Membrane
For a ruptured tympanic membrane with infection, use topical fluoroquinolone antibiotic drops (ciprofloxacin-dexamethasone or ofloxacin) as first-line treatment, never aminoglycoside-containing drops, and keep the ear dry. 1, 2
Initial Assessment
- Confirm the diagnosis with careful otoscopic examination, documenting perforation size and location 1
- Assess for modifying factors including diabetes, immunocompromised state, or signs of infection extension beyond the ear canal 1, 2
- Check for alarming features requiring urgent ENT referral: persistent pain, vertigo, facial paralysis, or profound sensorineural hearing loss suggesting ossicular chain disruption or inner ear damage 3, 4
Immediate Management: Ear Protection
- Keep the ear completely dry to prevent infection 1, 2
- Use ear plugs or cotton balls coated with petroleum jelly when showering 1, 2
- Avoid swimming until the perforation has healed 1, 2
- Never irrigate the ear canal when perforation is present or suspected, as this causes middle ear infection, vertigo, or ototoxicity 1, 2
Topical Antibiotic Therapy (If Infection Present)
Medication Selection:
- Use fluoroquinolone-based drops only: ciprofloxacin-dexamethasone or ofloxacin 1, 2
- Combination antibiotic-corticosteroid drops are superior to antibiotics alone 1, 2
- Topical therapy delivers drug concentrations 100-1000 times higher than oral antibiotics at the infection site 5, 1, 2
Critical Contraindications:
- Never use aminoglycoside-containing drops (neomycin, gentamicin, polymyxin B-neomycin combinations)—these cause severe permanent sensorineural hearing loss 1, 2
- Avoid alcohol-containing drops (painful and ototoxic in middle ear) 1, 2
- Avoid cerumenolytics and mineral oil 1, 2
Treatment Protocol:
- Clean the ear canal first by suctioning debris and discharge under microscopic guidance 1, 2
- Use tissue spears to absorb secretions before drop application 5, 1, 2
- For significant canal edema, place a compressed cellulose wick moistened with aqueous solution to facilitate drug delivery 1, 2
- Have patient lie with affected ear up for 3-5 minutes after instillation and "pump" the tragus several times 1
- Limit treatment to a single course of no more than 10 days to prevent otomycosis 1, 2
Systemic Antibiotics (Reserved for Specific Indications Only)
Add or switch to oral antibiotics only when: 1, 2
- Cellulitis of pinna or adjacent skin is present
- Extension of infection outside the ear canal
- Diabetes or immunocompromised state
- Topical therapy fails after 48-72 hours despite adequate drug delivery
Antibiotic Selection:
- First choice: Amoxicillin (targets S. pneumoniae, H. influenzae, M. catarrhalis) 2
- Second choice: Amoxicillin-clavulanate for β-lactamase-producing organisms 2
- Duration: 5-7 days 2
Pain Management
- Provide adequate analgesia as perforation pain can be intense 2
- Mild to moderate pain: acetaminophen or NSAIDs 2
- Moderate to severe pain: combination products with oxycodone or hydrocodone 2
Follow-Up and Reassessment
- If no response within 48-72 hours, reassess diagnosis and exclude other causes 1, 2
- Perform further aural debridement or culture persistent drainage 1, 2
- Only 4-8% of patients require oral antibiotic rescue therapy for persistent symptoms 5, 1
- Most traumatic perforations heal spontaneously within 4-12 weeks, with 94% healing rate 6, 7
Special Populations
- Children: All pediatric traumatic perforations in one study healed spontaneously without surgery 6
- Diabetic/immunocompromised patients: Lower threshold for systemic antibiotics and consider atraumatic cleaning with aural suctioning under microscopic guidance 2
Critical Pitfalls to Avoid
- If patient tastes ear drops, this indicates perforation—switch immediately to non-ototoxic preparation 1, 2
- Never use cotton-tipped applicators in the ear canal (cause further trauma or leave fibers) 5, 1, 2
- Even when tympanic membrane cannot be visualized due to canal edema or debris, assume perforation may be present and avoid aminoglycosides 1, 2
- Avoid pneumatic otoscopy when perforation suspected 4