Are tumor cells positive for CD34 (Cluster of Differentiation 34) and STAT6 (Signal Transducer and Activator of Transcription 6) on fine needle aspiration?

From the Research

Tumor Cell Characteristics

• Tumor cells in solitary fibrous tumors (SFTs) are often positive for CD34 and STAT6, as shown in studies 1, 2, 3.
• The presence of STAT6 and CD34 can be used as diagnostic markers for SFTs, especially when combined with other immunohistochemical markers 2, 3.

Fine Needle Aspiration (FNA) Biopsy

• FNA biopsy can be used to diagnose SFTs, but the cytomorphological features can be challenging to interpret 4, 3.
• Immunocytochemistry (ICC) performed on cell block sections can help confirm the diagnosis of SFT by showing positivity for STAT6, CD34, and other markers 4, 3.
• The cytomorphological features of SFT on FNA biopsy can include variable cellularity, spindle to elongated cells, and a metachromatically staining matrix material 3.

Immunohistochemical Markers

• STAT6 is a highly sensitive marker for SFTs, with a sensitivity of 96.2% in one study 2.
• CD34 is also a common marker for SFTs, but its sensitivity is lower than that of STAT6, at 88.7% in one study 2.
• Other markers, such as CD99 and Bcl-2, can also be positive in SFTs, but their sensitivity and specificity may vary 2.