From the Research
Efficacy of Exogenous Ketone Supplementation for Weight Loss
- The efficacy of exogenous ketone supplementation for weight loss is a topic of ongoing research, with some studies suggesting potential benefits 1, 2, 3, 4.
- A 2021 study published in Frontiers in Nutrition found that exogenous ketone salts did not further impact body composition responses to a hypocaloric ketogenic diet, although there was a trend towards less nitrogen loss with the ketone salt supplementation 2.
- Another study published in 2019 in Regulatory Toxicology and Pharmacology found that sustained exogenous ketosis using a ketone monoester had no effect on body weight or composition in healthy adults 5.
- A 2023 review published in Experimental Physiology highlighted the potential therapeutic applications of exogenous ketone supplementation, including improved metabolic health and cardiovascular function, although more research is needed to fully understand its effects 3.
- A 2022 review published in Frontiers in Nutrition discussed the use of ketogenic diets and exogenous ketone supplements as a strategy for therapeutic intervention, including their potential benefits for heart disease, epilepsy, and neurodegenerative disorders 4.
Key Findings
- Exogenous ketone supplementation may have potential benefits for weight loss, although more research is needed to fully understand its effects 1, 2, 3, 4.
- Ketogenic diets and exogenous ketone supplements can increase serum ketone bodies, providing an alternative energy fuel for high-energy demanding tissues 1, 2, 4.
- The safety and tolerability of exogenous ketone supplementation have been demonstrated in healthy adults, with minimal side effects reported 5.
Mechanisms and Potential Applications
- Exogenous ketone supplementation may have therapeutic potential for various diseases, including type 2 diabetes, neurological diseases, and heart failure 3.
- Further research is needed to fully understand the effects of exogenous ketone supplementation on human health and to explore its potential applications 2, 3, 4.