How to switch from Desorex (desogestrel) to Cerazette (desogestrel)?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: December 20, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Switching from Desorex to Cerazette

Since both Desorex and Cerazette contain the same active ingredient (desogestrel 75 mcg), you can switch directly from one to the other without any gap or need for backup contraception—simply start Cerazette the day after finishing your last Desorex pill. 1

Direct Switch Protocol

  • Take the first Cerazette pill the day immediately following your last Desorex pill, maintaining continuous daily dosing without interruption 1
  • No backup contraception is required because both medications contain identical active hormone (desogestrel 75 mcg) and you are maintaining continuous progestin coverage 1
  • Continue taking Cerazette at the same time each day (within 24 hours) to maintain contraceptive effectiveness, as progestin-only pills require strict timing 2

Key Considerations During the Switch

  • Contraceptive protection remains uninterrupted throughout the switch because the same progestin at the same dose maintains ovulation suppression 3, 4
  • No pregnancy testing is needed before switching, as you are transitioning between identical formulations while actively using contraception 1
  • Bleeding patterns should remain similar since the hormonal exposure is unchanged, though individual variation may occur 5, 3

Important Timing Reminders

  • Progestin-only pills have a narrow window for effectiveness—pills taken more than 3 hours late may compromise contraceptive protection and require backup contraception for 2 days 1
  • If you miss a pill during or after the switch, take it as soon as remembered and use backup contraception (condoms) or abstain from intercourse for the next 2 days 1

Common Pitfalls to Avoid

  • Do not create any gap between finishing Desorex and starting Cerazette—even a single day without pills requires 2 days of backup contraception 1
  • Do not wait for your next menstrual period to make the switch—continuous daily dosing is essential for progestin-only contraception 1
  • Do not assume you need backup contraception for this switch—this is only necessary when switching between different contraceptive methods or hormone types, not identical formulations 1

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Pharmacokinetic evaluation of desogestrel as a female contraceptive.

Expert opinion on drug metabolism & toxicology, 2014

Research

The effects of an oestrogen-free, desogestrel-containing oral contraceptive in women with cyclical symptoms: results from two studies on oestrogen-related symptoms and dysmenorrhoea.

The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception, 2007

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.